Safety profile of high-dose statin therapy in geriatric patients with stroke
| Autor: | Nidhi Bansal, Divey Manocha, Purva Gumaste, Sharon Brangman |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Diarrhea
Male Pediatrics medicine.medical_specialty Nausea chemistry.chemical_compound symbols.namesake medicine Secondary Prevention Humans Adverse effect Stroke Fisher's exact test Aged Retrospective Studies Aged 80 and over Myositis business.industry Case-control study Retrospective cohort study Alanine Transaminase General Medicine Myalgia medicine.disease chemistry Case-Control Studies symbols Population study Female Glycated hemoglobin medicine.symptom Hydroxymethylglutaryl-CoA Reductase Inhibitors business |
| Zdroj: | Southern medical journal. 106(12) |
| ISSN: | 1541-8243 |
| Popis: | OBJECTIVES Use of high-dose statin therapy (HDST) in patients with stroke became standard clinical practice after the Stroke Prevention by Aggressive Reduction in Cholesterol Levels (SPARCL) study, in which the mean age of the study population was approximately 63 years. Little data are available on the adverse effects of statins when used in high doses in adults older than 65 years. The objective of this study was to assess the magnitude of adverse effects of HDST in geriatric patients. METHODS This single-center, retrospective, case-control study was conducted at Upstate Medical University, Syracuse, New York. All patients older than 65 years admitted between 2008 and 2011 to the hospital's Upstate Stroke Center with acute stroke were eligible. Electronic medical records of 200 eligible patients were reviewed to collect demographic, clinical, and laboratory data. Patients on HDST (cases) were compared with those on low doses (controls) using the χ, Fisher exact (two-sided), and Student t tests. RESULTS One hundred cases (mean age 80.5 ± 7.7 years) were compared with 100 controls (mean age 78.9 ± 6.4 years). Sixty-seven percent were taking simvastatin. Ninety percent of the cases compared with 81% of the controls had ischemic stroke. The prevalence of elevated alanine aminotransferase (13%) and myositis (4%) was significantly higher in the cases than in the controls. Fourteen percent of the cases reported myalgias, 9% had nausea, and 6% had diarrhea. Seventy-three cases had low-density lipoprotein levels |
| Databáze: | OpenAIRE |
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