Increased plasma nitric oxide level associated with suicide attempt in depressive patients
| Autor: | Bun Hee Lee, Jong Woo Paik, Dokyung Yoon, Yong Ku Kim, Sung Woo Lee, Changsu Han |
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| Rok vydání: | 2006 |
| Předmět: |
Pharmacology
Adult Male Psychiatric Status Rating Scales medicine.medical_specialty Depressive Disorder Psychological Tests Suicide attempt Poison control Suicide Attempted Middle Aged Nitric Oxide Suicide prevention Rating scale Internal medicine Monoaminergic Injury prevention Blood plasma medicine Humans Female Psychiatry Psychology Biological Psychiatry Depression (differential diagnoses) |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 30(6) |
| ISSN: | 0278-5846 |
| Popis: | Background Nitric oxide (NO) is known to influence cerebral monoaminergic activity, including the activity of serotonin. We evaluated plasma NO metabolite (NOx) levels in depressive patients with and without a recent history of suicide attempt. Method Plasma NOx levels were measured in 39 depressive patients who had recently attempted suicide, 44 non-suicidal depressed patients, and 70 normal controls. The severity of depression was measured with the Hamilton's Depression Rating Scale. The lethality of the suicide attempt was scored using Weisman and Worden's risk-rescue rating scale and Lethality Suicide Attempt Rating Scale. Results Plasma NOx levels were significantly higher in suicidal depressive patients than non-suicidal depressive patients or normal control subjects (Z = − 2.472, p = 0.013). However, higher plasma NOx levels in suicidal depressive patients were significantly related to a lower lethality of suicide attempts and lower severity of depression. Conclusions Our study suggests that increased plasma NOx level is associated with suicide attempts in depressive patients. Moreover, higher plasma NOx level is related with suicide attempts in mild depressed patients. However, further studies are required to understand the role of NO system in depression and suicidal behavior. |
| Databáze: | OpenAIRE |
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