EAMI--exercise training in anterior myocardial infarction: an ongoing multicenter randomized study. Preliminary results on left ventricular function and remodeling. The EAMI Study Group
| Autor: | Carlo Schweiger, Alessandro Imparato, Pantaleo Giannuzzi, Luigi Sala, Marinella Gattone, Ugo Corrà, Amerigo Giordano, Claudio Malinverni, Pierluigi Temporelli, Luigi Tavazzi |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Anaerobic Threshold Myocardial Infarction Anterior myocardial infarction Critical Care and Intensive Care Medicine Ventricular Function Left Nyha class law.invention Randomized controlled trial law Internal medicine medicine Humans Prospective Studies Wall motion Analysis of Variance Ventricular function business.industry Electrocardiography in myocardial infarction Exercise Therapy Italy Echocardiography Exercise Test Cardiology Cardiology and Cardiovascular Medicine business Training program Anaerobic exercise |
| Zdroj: | Chest. 101:315S-321S |
| ISSN: | 0012-3692 |
| DOI: | 10.1378/chest.101.5.315s |
| Popis: | To determine the effects of a 6-month exercise training program on left ventricular (LV) function and remodeling, 49 consecutive patients (pts) with first Q anterior myocardial infarction (51 +/- 8 years), in I-II NYHA class, were studied 4 to 8 weeks after the acute episode and 6 months later by 2D-ECHO and upright bicycle ergometric test. At entry, pts were randomly allocated to physical training (T = 25pts) or control (C = 24pts). Global endocardial surface area (ESA), LV volumes and EF, extent of abnormal wall motion (%WMA), of regional dilatation (%REG DIL), and the shape distortion (DIST) index were analyzed. After 6 months, a significant increase in work capacity (4,589 +/- 1,417 to 5,379 +/- 1,485 KPM/min, p less than 0.03) and in lactic anaerobic threshold (45 +/- 13 to 63 +/- 15 W, p less than 0.01) was observed only in T. Initial ESA, EDV, EF, %WMA, %REG DIL, and DIST index were similar and they did not change after 6 months in both groups. However, pts with less than 40%EF had greater (p less than 0.0001) EDV and %WMA with marked DIST index at entry and showed further (p less than 0.01) deterioration after 6 months both in C and in T (EDV, ml/m2: 68 +/- 12 to 77 +/- 18 in C, 71 +/- 12 to 74 +/- 18 in T; %REG DIL: 39 +/- 20 to 49 +/- 24 in C, 32 +/- 12 to 35 +/- 23 in T; DIST index: 0.16 +/- 0.07 to 0.21 +/- 0.09 in C, 0.2 +/- 0.07 to 0.22 +/- 0.1 in T). These variables did not change in pts with greater than 40%EF. Thus, from these preliminary data, pts with less than 40%EF at entry are prone to further global and regional LV deterioration. Physical training does not seem to increase this spontaneous deterioration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|