Clinical Significance of Serum Soluble TNF Receptor I/II Ratio for the Differential Diagnosis of Tumor Necrosis Factor Receptor-Associated Periodic Syndrome From Other Autoinflammatory Diseases
| Autor: | Masato Yashiro, Tomoko Toma, Junko Yasumura, Satoshi Okada, Masaki Shimizu, Akihiro Yachie |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Familial Mediterranean fever Arthritis Gastroenterology Pathogenesis Hyalinosis Systemic 0302 clinical medicine familial Mediterranean fever Immunology and Allergy Child Original Research systemic juvenile idiopathic arthritis (sJIA) Middle Aged Periodic syndrome Receptors Tumor Necrosis Factor Type I Child Preschool Kawasaki disease (KD) Female Tumor necrosis factor alpha soluble tumor necrosis factor receptor lcsh:Immunologic diseases. Allergy Adult medicine.medical_specialty Adolescent Fever Immunology Enzyme-Linked Immunosorbent Assay Mucocutaneous Lymph Node Syndrome Diagnosis Differential Young Adult 03 medical and health sciences tumor necrosis factor receptor associated periodic syndrome (TRAPS) Predictive Value of Tests Internal medicine medicine Humans Receptors Tumor Necrosis Factor Type II Clinical significance business.industry Hereditary Autoinflammatory Diseases Infant Newborn Infant medicine.disease 030104 developmental biology Case-Control Studies Kawasaki disease Differential diagnosis lcsh:RC581-607 business Biomarkers 030215 immunology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Vol 11 (2020) |
| ISSN: | 1664-3224 |
| Popis: | Objectives: Genetic analysis of TNFRSF1A can confirm the diagnosis of tumor necrosis factor receptor-associated periodic syndrome (TRAPS), but interpretation of the pathogenesis of variants of unknown significance is sometimes required. The aim of this study was to evaluate the clinical significance of serum soluble tumor necrosis factor receptor type I (sTNFR-I)/II ratio to differentiate TRAPS from other autoinflammatory diseases. Methods: Serum sTNFR-I and sTNFR-II levels were measured using an enzyme-linked immunosorbent assay in patients with TRAPS (n = 5), familial Mediterranean fever (FMF) (n = 14), systemic juvenile idiopathic arthritis (s-JIA) (n = 90), and Kawasaki disease (KD) (n = 37) in the active and inactive phase, along with healthy controls (HCs) (n = 18). Results: In the active phase, the serum sTNFR-I/II ratio in patients with s-JIA, KD, and FMF was significantly elevated compared with that in HCs, whereas it was not elevated in patients with TRAPS. In the inactive phase, the serum sTNFR-I/II ratio in patients with s-JIA and FMF was significantly higher compared with that in HCs, and the ratio was lower in TRAPS patients than in patients with s-JIA and FMF. Conclusions: Low serum sTNFR-I/II ratio in the active and inactive phase might be useful for the differential diagnosis of TRAPS and other autoinflammatory diseases. |
| Databáze: | OpenAIRE |
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