In vitro drug release and percutaneous behavior of poloxamer-based hydrogel formulation containing traditional Chinese medicine

Autor: Chi Wai Kan, Clara Bik-San Lau, Frency S. F. Ng, Patrick C. L. Hui, Ping-Chung Leung, Eric Chun-Wai Wong, Huawen Hu, Xiaowen Wang, Wen Yi Wang, Ben Chan, Elaine Wat
Rok vydání: 2016
Předmět:
Drug
Swine
Skin Absorption
Sodium
media_common.quotation_subject
Composite number
chemistry.chemical_element
Poloxamer
02 engineering and technology
In Vitro Techniques
Pharmacology
Paeonia
010402 general chemistry
01 natural sciences
Hydrogel
Polyethylene Glycol Dimethacrylate
Colloid and Surface Chemistry
Gallic Acid
medicine
Animals
Medicine
Chinese Traditional
Physical and Theoretical Chemistry
Chromatography
High Pressure Liquid
Skin
Transdermal
media_common
Drug Carriers
Chromatography
Chemistry
Temperature
Surfaces and Interfaces
General Medicine
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
0104 chemical sciences
Carboxymethyl cellulose
Drug Liberation
Kinetics
Permeability (electromagnetism)
Carboxymethylcellulose Sodium
Poloxamer 407
0210 nano-technology
Algorithms
Drugs
Chinese Herbal
Biotechnology
medicine.drug
Zdroj: Colloids and Surfaces B: Biointerfaces. 148:526-532
ISSN: 0927-7765
DOI: 10.1016/j.colsurfb.2016.09.036
Popis: For the treatment of atopic dermatitis (AD), we have developed a transdermal functionalized textile therapy based on thermosensitive poloxamer 407 (P407) hydrogel containing a traditional Chinese herbal medicine. This study aims to investigate the effects of various formulation variables of P407/carboxymethyl cellulose sodium (P407/CMCs) composite hydrogel on the release of Cortex Moutan (CM) extract. Concentrations of P407 and CMCs showed significant influence on the release due to alteration of bulk viscosity of the system. An increase in pH values of release medium was found to appreciably impede the release of polar drug (CM) due to ionization. Elevated temperatures were also shown to facilitate the drug release. Moreover, the diffusional release behavior of CM from P407/CMCs composite hydrogel was found to follow the first-order kinetic model. Additionally, transdermal studies showed that permeability of the drug through the skin can be enhanced with addition of CMCs in the hydrogel formulation.
Databáze: OpenAIRE
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