Investigation of hepatic gluconeogenesis pathway in non-diabetic Asian Indians with non-alcoholic fatty liver disease using in vivo ((31)P) phosphorus magnetic resonance spectroscopy
| Autor: | R.M. Pandey, Arun Gupta, Rajeev Sharma, Vineet Ahuja, Anoop Misra, Naval K. Vikram, K. A. Danishad, Naranamangalam R. Jagannathan, Sanjeev Sinha |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Spectroscopy medicine.medical_treatment India chemistry.chemical_compound Insulin resistance Asian People Internal medicine Diabetes mellitus medicine Humans Ultrasonography Glucose tolerance test medicine.diagnostic_test Anthropometry business.industry Insulin Insulin tolerance test Fatty liver Gluconeogenesis nutritional and metabolic diseases Phosphorus Isotopes Glucose Tolerance Test Middle Aged medicine.disease digestive system diseases Fatty Liver Endocrinology chemistry Liver Case-Control Studies Insulin Resistance Cardiology and Cardiovascular Medicine business Phosphomonoesters |
| Zdroj: | Atherosclerosis. 203(1) |
| ISSN: | 1879-1484 |
| Popis: | To study hepatic gluconeogenesis pathway in non-diabetic Asian Indian males having non-alcoholic fatty liver disease (NAFLD) using in vivo ((31)P) phosphorous magnetic resonance spectroscopy (MRS) and correlate these data with anthropometry and insulin resistance.Forty non-diabetic patients with NAFLD and 20 healthy controls were divided into (i) obese with NAFLD (group I, n=20), (ii) non-obese with NAFLD (group II, n=20) and (iii) non-obese without NAFLD (group III, n=20). Anthropometric and biochemical profiles, short insulin tolerance test (SITT), liver ultrasound, and (31)P MRS (to determine hepatic gluconeogenesis metabolite; phosphomonoesters (PMEs), inorganic phosphate (Pi) and their ratios with respect to ATP) were done.Insulin resistance (Kitt value) was highest in group I (p0.05; compared to other two groups), but was also higher in group II as compared to group III (p=ns). The values of PME/Pi, PME/gammaATP, PME/betaATP, PME/tATP ratios were higher (p0.05) in group I compared to other two groups. Interestingly, non-obese subjects with NAFLD also showed more derangements of hepatic gluconeogenesis metabolites than non-obese subjects without NAFLD. Positive correlation was observed between PME and other ratios in relation to body mass index, waist circumference, body fat percentage and fasting serum insulin levels in all the three groups.Derangements in hepatic gluconeogenesis as assessed non-invasively using (31)P MRS, was observed in obese and non-obese, non-diabetic Asian Indians with NAFLD. Further research is warranted whether this investigation in NAFLD subjects could be developed as a non-invasive tool to assess those predisposed to develop hyperglycemia. |
| Databáze: | OpenAIRE |
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