Prevalence and Familial Aggregation of Schistosomal Liver Morbidity in Kenya: Evaluation by New Ultrasound Criteria
| Autor: | Ronald E. Blanton, John H. Ouma, Charles H. King, Philip Magak, H. Curtis Kariuki, F. W. Thiongo, Jeffry A. Bailey, Gabriel Mbugua, Anthony E. Butterworth, Eric M. Muchiri |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Adolescent Population macromolecular substances Disease Disease Vectors Fibrosis Internal medicine Epidemiology Prevalence medicine Genetic predisposition Animals Humans Immunology and Allergy Genetic Predisposition to Disease Child education Aged Ultrasonography Family Health education.field_of_study Biomphalaria biology Portal Vein business.industry Age Factors Infant Newborn Infant Family aggregation Middle Aged biology.organism_classification medicine.disease Kenya Schistosomiasis mansoni Infectious Diseases Liver Child Preschool Immunology Female Schistosoma mansoni Hepatic fibrosis business |
| Zdroj: | The Journal of Infectious Diseases. 183:960-966 |
| ISSN: | 1537-6613 0022-1899 |
| DOI: | 10.1086/319247 |
| Popis: | Severe periportal fibrosis is not an inevitable consequence of infection with Schistosoma mansoni. Genetic predisposition may be a deciding factor in the development of disease. To assess the contribution of genetic factors in the severity of hepatic fibrosis, the degree of familial aggregation was determined in a Kenyan population. Schistosomal fibrosis was identified with hepatic ultrasound and newly proposed World Health Organization criteria, which include both qualitative and quantitative observations. These 2 aspects of the criteria correlated well with one another. The peak prevalence of ultrasound proven fibrosis trailed 5-10 years behind peak prevalence of infection and declined sharply after age 50 years. This pattern was consistent with either resolution of severe fibrosis over 10-20 years or early death of those severely affected. Genetic predisposition appears to be a weak factor in the development of severe disease in this population, since no household or familial aggregation could be identified. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|