Diurnal effects of enriched environment on immediate early gene expression in the rat brain
| Autor: | Sven-Anders Bergström, Tommy Olsson, Per Dahlqvist, Annica Rönnbäck |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Receptors Steroid medicine.medical_specialty Gene Expression Receptors Cytoplasmic and Nuclear Hippocampus Environment Biology Immediate early protein Immediate-Early Proteins Rats Sprague-Dawley Internal medicine Gene expression Neuroplasticity Nuclear Receptor Subfamily 4 Group A Member 1 medicine Animals RNA Messenger Molecular Biology Early Growth Response Protein 2 Early Growth Response Protein 1 Analysis of Variance Environmental enrichment Neuronal Plasticity General Neuroscience Brain Long-term potentiation Darkness Circadian Rhythm Rats DNA-Binding Proteins Endocrinology NMDA receptor Neurology (clinical) Immediate early gene Transcription Factors Developmental Biology |
| Zdroj: | Brain Research. 1046:137-144 |
| ISSN: | 0006-8993 |
| Popis: | Rodents housed in an enriched environment (EE) show increased neuronal plasticity with enhanced long-term potentiation and memory performance. We report an EE-induced increase in NGFI-A and Krox-20 mRNA expression exclusively during the dark period of the day. In addition, EE-housed rats showed considerable diurnal variation in NGFI-A, Krox-20, and NGFI-B mRNA expression which was absent in single-housed rats. Thus, EE-induced molecular changes are more evident during the dark phase when the rats have higher motor and exploratory activity. This is important to take into account in future studies of molecular mediators of experience-dependent neuronal plasticity. |
| Databáze: | OpenAIRE |
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