Three-month B vitamin supplementation in pre-school children affects folate status and homocysteine, but not cognitive performance
| Autor: | Mareile Niesser, Judith Weichert, Wolfgang Peissner, Vanessa Martens, Sheila Wiseman, Hans Demmelmair, Moritz Heene, Berthold Koletzko, Uschi Handel, Markus Bühner, Astrid A. M. Rauh-Pfeiffer, Diego Moretti |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Homocysteine Urinary system Population Methylmalonic acid Medicine (miscellaneous) law.invention chemistry.chemical_compound Cognition Folic Acid Double-Blind Method Randomized controlled trial law Germany Internal medicine Humans Medicine Vitamin B12 Effects of sleep deprivation on cognitive performance Child education education.field_of_study Nutrition and Dietetics business.industry 3. Good health Calcium Dietary Vitamin B 12 B vitamins Memory Short-Term Endocrinology chemistry Child Preschool Dietary Supplements Vitamin B Complex Female business Biomarkers Methylmalonic Acid |
| Zdroj: | European Journal of Nutrition |
| ISSN: | 1436-6215 1436-6207 |
| DOI: | 10.1007/s00394-013-0647-y |
| Popis: | Suboptimal vitamin B status might affect cognitive performance in early childhood. We tested the hypothesis that short-term supplementation with folic acid and selected B vitamins improves cognitive function in healthy children in a population with relatively low folate status. We screened 1,002 kindergarten children for suboptimal folate status by assessing the total urinary para-aminobenzoylglutamate excretion. Two hundred and fifty low ranking subjects were recruited into a double blind, randomized, controlled trial to receive daily a sachet containing 220 μg folic acid, 1.1 mg vitamin B2, 0.73 mg B6, 1.2 μg B12 and 130 mg calcium, or calcium only for 3 months. Primary outcomes were changes in verbal IQ, short-term memory and processing speed between baseline and study end. Secondary outcomes were urinary markers of folate and vitamin B12 status, acetyl-para-aminobenzoylglutamate and methylmalonic acid, respectively, and, in a subgroup of 120 participants, blood folate and plasma homocysteine. Pre- and post-intervention cognitive measurements were completed by 115 children in the intervention and 122 in the control group. Compared to control, median blood folate increased by about 50 % (P for difference, P |
| Databáze: | OpenAIRE |
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