Transmissibility of MERS-CoV Infection in Closed Setting, Riyadh, Saudi Arabia, 2015

Autor: Malik Peiris, Abdullah M. Assiri, Abdulaziz A. BinSaeed, Hassan El Bushra, Maria D. Van Kerkhove, Sadoof Alaswad, Ranawaka A.P.M. Perera
Rok vydání: 2019
Předmět:
Adult
Microbiology (medical)
Oropharyngeal swab
Veterinary medicine
Universities
Epidemiology
Middle East respiratory syndrome coronavirus
030231 tropical medicine
Saudi Arabia
lcsh:Medicine
Transmissibility of MERS-CoV Infection in Closed Setting
Riyadh
Saudi Arabia
2015
medicine.disease_cause
Disease cluster
Neutralization
Disease Outbreaks
lcsh:Infectious and parasitic diseases
Serology
MERS-CoV
03 medical and health sciences
0302 clinical medicine
Risk Factors
human-to-human transmission
Humans
Medicine
Air Conditioning
viruses
lcsh:RC109-216
030212 general & internal medicine
business.industry
lcsh:R
Riyadh
medicine.disease
Pathogenicity
outbreak investigation
Titer
Infectious Diseases
Synopsis
Housing
Middle East respiratory syndrome
Female
seroepidemiology
Coronavirus Infections
business
Zdroj: Emerging Infectious Diseases
Emerging Infectious Diseases, Vol 25, Iss 10, Pp 1802-1809 (2019)
ISSN: 1080-6059
1080-6040
DOI: 10.3201/eid2510.190130
Popis: To investigate a cluster of Middle East respiratory syndrome (MERS) cases in a women-only dormitory in Riyadh, Saudi Arabia, in October 2015, we collected epidemiologic information, nasopharyngeal/oropharyngeal swab samples, and blood samples from 828 residents during November 2015 and December 2015–January 2016. We found confirmed infection for 19 (8 by reverse transcription PCR and 11 by serologic testing). Infection attack rates varied (2.7%–32.3%) by dormitory building. No deaths occurred. Independent risk factors for infection were direct contact with a confirmed case-patient and sharing a room with a confirmed case-patient; a protective factor was having an air conditioner in the bedroom. For 9 women from whom a second serum sample was collected, antibodies remained detectable at titers >1:20 by pseudoparticle neutralization tests (n = 8) and 90% plaque-reduction neutralization tests (n = 2). In closed high-contact settings, MERS coronavirus was highly infectious and pathogenicity was relatively low.
Databáze: OpenAIRE
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