MGP T-138C Polymorphism (TT Genotype) is Associated with Vascular Calcification Incidence in Indonesian Regular Hemodialysis Patients
Autor: | Syafrizal Nasution, Muhammad Hanif Wibowo, Riri Andri Muzasti |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Kidney lcsh:R5-920 biology business.industry medicine.medical_treatment Medicine (miscellaneous) nutritional and metabolic diseases Disease medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology medicine.anatomical_structure Internal medicine Genotype Matrix gla protein medicine biology.protein Hemodialysis Allele Restriction fragment length polymorphism business lcsh:Medicine (General) Kidney disease |
Zdroj: | Indonesian Biomedical Journal, Vol 12, Iss 4, Pp 320-324 (2020) |
ISSN: | 2355-9179 2085-3297 |
Popis: | BACKGROUND: Vascular calcification contributes greatly to the incidence of cardiovascular disease. Previously, vascular calcification was considered as a passive process caused by the mineral deposition from the circulation. Nowadays, researchers have found inhibitors and promoter factors from vascular calcification, one of which is the matrix gla protein (MGP). MGP levels depend on the gene that encodes them. The MGP T-138C polymorphism is one of the most common causes of vascular calcification.METHODS: This was a case-control study involving 86 chronic kidney disease (CKD) patients who underwent regular hemodialysis in Rasyida Kidney Hospital, Medan, Indonesia. Vascular calcification was determined from lateral and posteroanterior abdominal X-ray. The MGP T-138 C polymorphism was analyzed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).RESULTS: The TT/TC genotype associates with the incidence of vascular calcification with OR of 3.52, 95% CI: 1.23-10.106 (p-value |
Databáze: | OpenAIRE |
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