BAFF mediates survival of peripheral immature B lymphocytes
| Autor: | Jeffrey L. Browning, Teresa G. Cachero, Fabienne Mackay, Jürg Tschopp, Fang Qian, Marcel Batten, Joanna R Groom, Pascal Schneider |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
transitional B lymphocyte
Cell Survival Immunology B-cell receptor Naive B cell B-Lymphocyte Subsets antigen receptor Biology Mice B cell homeostasis hemic and lymphatic diseases B-Cell Activating Factor medicine Immunology and Allergy Animals B-cell activating factor BAFF receptor B cell Cells Cultured Tumor Necrosis Factor-alpha Transmembrane activator and CAML interactor B cell maturation autoimmunity Models Immunological Membrane Proteins Cell Differentiation Hematopoietic Stem Cells Cell biology B-1 cell medicine.anatomical_structure Autoimmunity B-Lymphocyte Subsets/cytology B-Lymphocyte Subsets/immunology Hematopoietic Stem Cells/cytology Hematopoietic Stem Cells/immunology Membrane Proteins/metabolism Spleen/cytology Spleen/immunology Tumor Necrosis Factor-alpha/metabolism Original Article spleen |
| Zdroj: | Journal of Experimental Medicine, vol. 192, no. 10, pp. 1453-1466 The Journal of Experimental Medicine |
| Popis: | B cell maturation is a very selective process that requires finely tuned differentiation and survival signals. B cell activation factor from the TNF family (BAFF) is a TNF family member that binds to B cells and potentiates B cell receptor (BCR)-mediated proliferation. A role for BAFF in B cell survival was suggested by the observation of reduced peripheral B cell numbers in mice treated with reagents blocking BAFF, and high Bcl-2 levels detected in B cells from BAFF transgenic (Tg) mice. We tested in vitro the survival effect of BAFF on lymphocytes derived from primary and secondary lymphoid organs. BAFF induced survival of a subset of splenic immature B cells, referred to as transitional type 2 (T2) B cells. BAFF treatment allowed T2 B cells to survive and differentiate into mature B cells in response to signals through the BCR. The T2 and the marginal zone (MZ) B cell compartments were particularly enlarged in BAFF Tg mice. Immature transitional B cells are targets for negative selection, a feature thought to promote self-tolerance. These findings support a model in which excessive BAFF-mediated survival of peripheral immature B cells contributes to the emergence and maturation of autoreactive B cells, skewed towards the MZ compartment. This work provides new clues on mechanisms regulating B cell maturation and tolerance. |
| Databáze: | OpenAIRE |
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