Is the Combination of 5-Fluorouracil and Folinic Acid Effective in Advanced Gastric Carcinoma? Results of a pilot study and review of the literature

Autor: C Nicolaides, N. Pavlidis, E Briassoulis, G. Klouvas
Rok vydání: 1994
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Fluorouracil/administration & dosage/adverse effects
medicine.medical_treatment
030106 microbiology
Leucovorin
Pilot Projects
Adenocarcinoma/*drug therapy/mortality
Adenocarcinoma
Gastroenterology
Stomach Neoplasms/*drug therapy/mortality
03 medical and health sciences
Folinic acid
0302 clinical medicine
Stomach Neoplasms
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
Carcinoma
Humans
Medicine
Pharmacology (medical)
Stomatitis
Aged
Pharmacology
Chemotherapy
business.industry
Stomach
Middle Aged
medicine.disease
Surgery
Regimen
Infectious Diseases
medicine.anatomical_structure
Oncology
Antineoplastic Combined Chemotherapy Protocols/adverse effects/*therapeutic use
Fluorouracil
030220 oncology & carcinogenesis
Toxicity
Female
Leucovorin/administration & dosage/adverse effects
business
medicine.drug
Zdroj: Journal of Chemotherapy. 6:417-422
ISSN: 1973-9478
1120-009X
DOI: 10.1080/1120009x.1994.11741177
Popis: The main purpose of this trial was to investigate the activity of a less toxic regimen in patients with advanced gastric carcinoma regarding response rate and survival. We report on a pilot study of 20 patients treated with the combination of 5-fluorouracil and folinic acid. 5-fluorouracil was administered at a daily dose of 450 mg/m2 followed by folinic acid 200 mg/m2 for four consecutive days every four weeks. The overall response rate was 15% with one complete and two partial responders. The median duration of response was 11, 10 and 10 months respectively. The median survival of all patients was 9 months. Toxicity was mild and consisted primarily of diarrhea. Stomatitis and myelosuppression occurred rarely. In conclusion, the combination of 5-fluorouracil and folinic acid has moderate activity in gastric cancer, while median survival appears similar to the other more intensive regimens. The combination is very well tolerated with minimal toxicity. A detailed review of the literature regarding the effectiveness of the above regimens on response rate, overall survival and toxicity is also presented. J Chemother
Databáze: OpenAIRE
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