Pitfall in immunohistochemical staining for thyroglobulin in case of thyroid metastasis from lung carcinoma
| Autor: | Chutintorn Sriphrapradang, Palapong Chayangsu, Napatt Kanjanahattakij, Sasiphat Chontong, Wasana Kanoksil |
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| Rok vydání: | 2015 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty lcsh:Cytology business.industry medicine.medical_treatment CytoJournal Quiz Case Thyroid Neck mass Thyroid Transcription Factor 1 Papanicolaou stain medicine.disease Pathology and Forensic Medicine medicine.anatomical_structure Calcitonin Cytology Carcinoma Medicine Thyroglobulin lcsh:QH573-671 medicine.symptom business |
| Zdroj: | CytoJournal CytoJournal, Vol 12, Iss 1, Pp 27-27 (2015) |
| ISSN: | 0974-5963 |
| Popis: | A 73-year-old female presented with an enlarging neck mass over the last 2 years. She then started experiencing hoarseness, dysphagia, and weight loss for 5 months. Physical examination showed an irregular and hard consistency mass with a diameter of 4 cm occupying the left lobe and isthmus of the thyroid gland. Fine-needle aspiration biopsy (FNAB) was performed and the cytology specimen revealed sheets of neoplastic cells with enlarged, hyperchromatic, slightly pleomorphic nuclei, prominent nucleoli, and brownish pigment inside the tumor cells [Figure 1a]. The definitive diagnosis could not be made from cytology alone. Immunohistochemical staining was requested with positive results for thyroglobulin [Figure 1b], thyroid transcription factor 1 (TTF-1) [Figure 1c], but negative for calcitonin. Figure 1 (a) Fine-needle aspiration thyroid showed a background of cystic lesion (foamy cells) with few of neoplastic cells and a sheet of degenerative follicular cells (Papanicolaou stain, ×400), (b) cell block preparation showed the immunoreactivity ... |
| Databáze: | OpenAIRE |
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