A novel technique of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration in the diagnosis of submucosal recurrence of nasopharyngeal carcinoma after chemoradiotherapy
| Autor: | Rui Zhao, Ran-Ling Wang, Shang-Zhi Hu, Xi Chen, Sheng-Ping Li, Ling-Xiao Zhou, Zhen-Ming Zhang, Yu Bao, Wu-Song Liu |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Biopsy medicine Humans Radiology Nuclear Medicine and imaging Angiosarcoma Endoscopic Ultrasound-Guided Fine Needle Aspiration Pathological Ultrasonography Transnasopharyngeal Nasopharyngeal Carcinoma medicine.diagnostic_test business.industry Nasopharyngeal Neoplasms Magnetic resonance imaging Chemoradiotherapy Hematology medicine.disease Radiation therapy stomatognathic diseases Oncology Nasopharyngeal carcinoma Radiology business |
| Zdroj: | Radiotherapy and Oncology. 165:14-19 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/j.radonc.2021.10.002 |
| Popis: | Background Recurrence of nasopharyngeal carcinoma (NPC) after chemoradiotherapy is common, but submucosal recurrence of NPC is rare. The final pathological results determine the optimal therapeutic schedule for treatment of NPC recurrence, but tissue retrieval from submucosal lesions is usually difficult. The present study aimed to assess the safety and efficacy of a novel approach of endonasopharyngeal ultrasound-guided transnasopharyngeal needle aspiration (ENUS-TNNA) for submucosal neoplasms in patients with suspected NPC recurrence. Methods Between March 2017 and June 2021, 11 post-chemoradiotherapy patients with suspected magnetic resonance imaging (MRI) findings of submucosal recurrence of NPC underwent ENUS-TNNA. The safety and effectiveness of using ENUS-TNNA to sample submucosal neoplasms were evaluated. Results Needle aspiration biopsies were performed without any incidences in all cases. Out of the 11 patients, nine were diagnosed with submucosal recurrence of NPC via histopathological or cytological evaluations. Of the two puncture-negative cases, one patient had atypical imaging findings and clinical manifestations and was therefore followed-up using MRI. After follow-up for 3 years, this patient was still considered to be cancer-free due to the shrinking diameters of the submucosal lesions. For the other puncture-negative patient, submucosal biopsy samples were obtained using a surgical method. Pathological examination of these biopsies revealed that an angiosarcoma had developed after radiotherapy. There were no severe complications that occurred during the ENUS-TNNA procedure. Conclusion ENUS-TNNA is a safe, effective, and minimally invasive approach to obtain tissue samples from the submucosal region of the nasopharynx for patients with suspected NPC recurrence. |
| Databáze: | OpenAIRE |
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