Preliminary Observations on a New Derivative of Isoniazid (Ro 2-4969)

Autor:	Helen A. Dickie, Frank C. Larson
Rok vydání:	1953
Předmět:	Drug Gastrointestinal tract Chemistry media_common.quotation_subject Isoniazid Nicotinic Acids Absorption (skin) Pharmacology General Biochemistry Genetics and Molecular Biology Isomerism medicine Solubility Cumulative effect media_common medicine.drug
Zdroj:	Experimental Biology and Medicine. 84:301-303
ISSN:	1535-3699 1535-3702
DOI:	10.3181/00379727-84-20624
Popis:	Summary1. Ro 2-4969, a compound of low solubility, related to isoniazid, has been administered experimentally to human subjects to determine the rate and extent of absorption from the gastrointestinal tract. 2. The compound or its derivatives appeared in the plasma and, probably because of slow absorption, detectable and clinically significant amounts remained for a longer period than when the highly soluble isoniazid was administered. 3. The drug administered in a single daily dose of 10 mg/kg/day was found to maintain drug concentrations of one μg/ml of plasma without dangerous cumulative effect. 4. No toxic reactions have been observed in 26 patients treated for 2 months or more.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb567caded694da57fafedc4a2d181d1 https://doi.org/10.3181/00379727-84-20624 Zobrazit plný text záznamu