Role of metoprolol, B1-adrenoceptor antagonist, thromboxane A2 and nitric oxide in CsA-induced hypertension
| Autor: | G.K. Oriji |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Adrenergic beta-Antagonists Clinical Biochemistry Aorta Thoracic In Vitro Techniques Nitric Oxide Nitric oxide Rats Sprague-Dawley Thromboxane A2 chemistry.chemical_compound Internal medicine medicine.artery medicine Animals Protein Kinase C Protein kinase C Metoprolol Aorta Antagonist Cell Biology Rats Enzyme Activation Endocrinology Eicosanoid chemistry Hypertension Cyclosporine Immunosuppressive Agents medicine.drug |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 68:233-238 |
| ISSN: | 0952-3278 |
| Popis: | Chronic treatment with cyclosporine A (CsA), a potent immunosuppressive agent, is associated with the development of arterial hypertension. The effect of CsA on vascular responses was determined in Sprague-Dawley rats and rat aortic rings. Male rats weighing 250-300 g were given either CsA (25mg/kg/day) in olive oil or vehicle by intraperitoneal (ip) injection for 7 days. CsA administration produced a 42% increase (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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