Ferrostatin-1 Alleviates White Matter Injury Via Decreasing Ferroptosis Following Spinal Cord Injury
| Autor: | Hua Feng, Jishu Xian, Yongjie Zou, Jun Zhong, Shengli Hu, Long Wang, Linbo Yuan, Xingsen Xue, Zhouyang Jiang, Hong Su, Jiantao Shi, Hongfei Ge, Tunan Chen |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Neurology Traumatic brain injury Iron Central nervous system Neuroscience (miscellaneous) Motor Activity Phenylenediamines White matter Cellular and Molecular Neuroscience medicine Animals Ferroptosis Rats Wistar Spinal cord injury Stroke Spinal Cord Injuries Neurons Oligodendrocyte Precursor Cells Cyclohexylamines Microglia business.industry Recovery of Function medicine.disease White Matter Oligodendrocyte Rats medicine.anatomical_structure Spinal Cord Astrocytes Female Reactive Oxygen Species business Neuroscience |
| Zdroj: | Molecular Neurobiology. 59:161-176 |
| ISSN: | 1559-1182 0893-7648 |
| Popis: | Spinal cord injury (SCI), a devastating neurological impairment, usually imposes a long-term psychological stress and high socioeconomic burden for the sufferers and their family. Recent researchers have paid arousing attention to white matter injury and the underlying mechanism following SCI. Ferroptosis has been revealed to be associated with diverse diseases including stroke, cancer, and kidney degeneration. Ferrostatin-1, a potent inhibitor of ferroptosis, has been illustrated to curb ferroptosis in neurons, subsequently improving functional recovery after traumatic brain injury (TBI) and SCI. However, the role of ferroptosis in white matter injury and the therapeutic effect of ferrostatin-1 on SCI are still unknown. Here, our results indicated that ferroptosis played a pivotal role in the secondary white matter injury, and ferrostatin-1 could reduce iron and reactive oxygen species (ROS) accumulation and downregulate the ferroptosis-related genes and its products of IREB2 and PTGS2 to further inhibit ferroptosis in oligodendrocyte, finally reducing white matter injury and promoting functional recovery following SCI in rats. Meanwhile, the results demonstrated that ferrostatin-1 held the potential of inhibiting the activation of reactive astrocyte and microglia. Mechanically, the present study deciphers the potential mechanism of white matter damage, which enlarges the therapeutic effects of ferrostatin-1 on SCI and even in other central nervous system (CNS) diseases existing ferroptosis. |
| Databáze: | OpenAIRE |
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