Arc/Arg3.1 mediates a critical period for spatial learning and hippocampal networks
| Autor: | Sabine Graf, Dietmar Kuhl, Ora Ohana, Ute Süsens, Sergio Castro-Gomez, Dirk Isbrandt, Jasper Grendel, Daniel Mensching, Xiaoyan Gao, Lars Binkle |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cyclin-Dependent Kinase Inhibitor p21 Memory Long-Term Period (gene) media_common.quotation_subject Spatial Learning physiology [Gene Expression Regulation] physiology [Hippocampus] Hippocampus Sensory system Nerve Tissue Proteins Hippocampal formation Biology metabolism [Cyclin-Dependent Kinase Inhibitor p21] metabolism [Cytoskeletal Proteins] physiology [Memory Long-Term] 03 medical and health sciences Mice 0302 clinical medicine Perception Animals activity regulated cytoskeletal-associated protein genetics [Nerve Tissue Proteins] media_common genetics [Cytoskeletal Proteins] Neurons physiology [Spatial Learning] Multidisciplinary Arc (protein) metabolism [Nerve Tissue Proteins] Neuronal Plasticity Artificial neural network Behavior Animal genetics [Cyclin-Dependent Kinase Inhibitor p21] Biological Sciences physiology [Neurons] Cytoskeletal Proteins 030104 developmental biology Gene Expression Regulation Spatial learning ddc:500 Neuroscience 030217 neurology & neurosurgery Gene Deletion |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America 115(49), 12531-12536 (2018). doi:10.1073/pnas.1810125115 |
| DOI: | 10.1073/pnas.1810125115 |
| Popis: | During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and memory but remain elusive and poorly understood. Here, we present evidence that the activity-regulated and memory-linked gene Arc/Arg3.1 is transiently up-regulated in the hippocampus during the first postnatal month. Conditional removal of Arc/Arg3.1 during this period permanently alters hippocampal oscillations and diminishes spatial learning capacity throughout adulthood. In contrast, post developmental removal of Arc/Arg3.1 leaves learning and network activity patterns intact. Long-term memory storage continues to rely on Arc/Arg3.1 expression throughout life. These results demonstrate that Arc/Arg3.1 mediates a critical period for spatial learning, during which Arc/Arg3.1 fosters maturation of hippocampal network activity necessary for future learning and memory storage. |
| Databáze: | OpenAIRE |
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