Sensing and regulation of cell volume – we know so much and yet understand so little: TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role?
| Autor: | Nanna MacAulay, Brian Roland Larsen, Trine Lisberg Toft-Bertelsen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
TRPV4 Cell volume Biophysics osmo-sensing TRPV Cation Channels Review Biochemistry 03 medical and health sciences 0302 clinical medicine Animals aquaporins Ion channel Cell Size Chemistry Cell swelling transient receptor potential vanilloid 4 channel volume-sensitive ion channels Rats 030104 developmental biology Volume (thermodynamics) Astrocytes Molecular mechanism Volume response volume regulation Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Channels Toft-Bertelsen, T L, Larsen, B R & MacAulay, N 2018, ' Sensing and regulation of cell volume-we know so much and yet understand so little : TRPV4 as a sensor of volume changes but possibly without a volume-regulatory role? ', Channels (Austin), vol. 12, no. 1, pp. 100-108 . https://doi.org/10.1080/19336950.2018.1438009 |
| ISSN: | 1933-6969 1933-6950 |
| DOI: | 10.1080/19336950.2018.1438009 |
| Popis: | Cellular volume changes lead to initiation of cell volume regulatory events, the molecular identity of which remains unresolved. We here discuss experimental challenges associated with investigation of volume regulation during application of large, non-physiological osmotic gradients. The TRPV4 ion channel responds to volume increase irrespectively of the molecular mechanism underlying cell swelling, and is thus considered a sensor of volume changes. Evidence pointing towards the involvement of TRPV4 in subsequent volume regulatory mechanisms is intriguing, yet far from conclusive. We here present an experimental setting with astrocytic cell swelling in the absence of externally applied osmotic gradients, and the lack of evidence for involvement of TRPV4 in this regulatory volume response. Our aim with these new data and the preceding discussion is to stimulate further experimental effort in this area of research to clarify the role of TRPV4 and other channels and transporters in regulatory volume responses. |
| Databáze: | OpenAIRE |
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