Synthetic ratiometric fluorescent probes for detection of ions

Autor:	Nahyun Kwon, Juyoung Yoon, Sanghyun Park, Injae Shin, Jee Hyeon Lee
Rok vydání:	2019
Předmět:	Ions Molecular Structure 010405 organic chemistry Chemistry Nanotechnology General Chemistry 010402 general chemistry 01 natural sciences Fluorescence 0104 chemical sciences Ion Zinc Organic dye Molecule Humans Copper Fluorescent Dyes
Zdroj:	Chemical Society reviews. 49(1)
ISSN:	1460-4744 2015-2019
Popis:	Metal cations and anions are essential for versatile physiological processes. Dysregulation of specific ion levels in living organisms is known to have an adverse effect on normal biological events. Owing to the pathophysiological significance of ions, sensitive and selective methods to detect these species in biological systems are in high demand. Because they can be used in methods for precise and quantitative analysis of ions, organic dye-based ratiometric fluorescent probes have been extensively explored in recent years. In this review, recent advances (2015-2019) made in the development and biological applications of synthetic ratiometric fluorescent probes are described. Particular emphasis is given to organic dye-based ratiometric fluorescent probes that are designed to detect biologically important and relevant ions in cells and living organisms. Also, the fundamental principles associated with the design of ratiometric fluorescent probes and perspectives about how to expand their biological applications are discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4c7e4ed3b2b6dd697ddca783e386be https://pubmed.ncbi.nlm.nih.gov/31750471 Zobrazit plný text záznamu