The Roles of Transmembrane Mucins Located on Chromosome 7q22.1 in Colorectal Cancer
| Autor: | Hussain Almasmoum |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
MUC12 Colorectal cancer colorectal cancer Review MUC17 Biology Malignancy chromosome 7q22.1 law.invention 03 medical and health sciences 0302 clinical medicine law medicine Gene neoplasms MUC1 Mucin Chromosome mucins medicine.disease Transmembrane protein digestive system diseases 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research MUC3 Suppressor |
| Zdroj: | Cancer Management and Research |
| ISSN: | 1179-1322 |
| Popis: | Colorectal cancer (CRC) is one of the most common types of cancers. It is associated with a poor prognosis and high mortality. The role of mucins (MUCs) in colon tumorigenesis is unclear, but it might be significant in the progression of malignancy. Some mucins, such as MUC1 and MUC13, act as oncogenes, whereas others, such as MUC2 and MUC6, are tumor suppressors. However, there are still mucins with unidentified roles in CRC. In this review, we discuss the reported roles of mucins in CRC. Moreover, we review the capability of the mucin family to serve as a sensitive and specific histopathological marker for the early diagnosis of CRC. Lastly, the role of mucin genes clustered on chromosome 7q22 in CRC and other cancers is also discussed. |
| Databáze: | OpenAIRE |
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