| Popis: |
This study investigated the various effects of Sildenafil citrate on the liver, kidney and heart of malealbino rats. Twenty eight male rats randomly divided into 4 groups and weighing 131-214g were used. While the animals in group 1 (control) received food and water only, those in the study groups 2,3&4 respectively received 25mg/kg, 50mg/kg and 100mg/kg of Sildenafil citrate orally, daily for 4 weeks. All animals were sacrificed and blood samples collected by cardiac puncture for analysis of biochemical parameters. The rats Liver, kidneys and hearts were subjected to histopathological tests. Study results showed no changes in food consumption, fluid intake, body weight and relative organ weight of the animals. The animals in group 4 showed significant increase in mean Lactate dehydrogenase and Aspartate aminotransferase ⃰(Palbino rats. Sildenafil citrate has potential toxic effects on the liver, kidney and heart of studied rats with higher doses. Conclusion: Sildenafil citrate has potential toxic effects on the liver, kidney and heart of malealbino ratsespecially with higher doses. |
