Pathogens, patterns of pneumonia, and epidemiologic risk factors associated with respiratory disease in recently weaned cattle in Ireland
| Autor: | Gerard M. Murray, Joseph P. Cassidy, D. J. Sammin, Bernadette Earley, Mìcheàl J. Casey, Simon J. More, Hywel J. Ball, Colin J. Bell, Rónan G. O’Neill, Tracy A. Clegg, William Byrne, Máire C. McElroy |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pasteurella multocida 040301 veterinary sciences Cattle Diseases Weanling Bovine respiratory disease Respiratory Syncytial Virus Bovine Biology Polymerase Chain Reaction 0403 veterinary science 03 medical and health sciences Bronchopneumonia medicine Animals Mannheimia haemolytica Parainfluenza Virus 3 Bovine General Veterinary Respiratory disease 04 agricultural and veterinary sciences medicine.disease Immunohistochemistry Animals Suckling respiratory tract diseases Pneumonia 030104 developmental biology Immunology Cattle Autopsy Ireland |
| Zdroj: | Journal of Veterinary Diagnostic Investigation. 29:20-34 |
| ISSN: | 1943-4936 1040-6387 |
| Popis: | We examined the pathogens, morphologic patterns, and risk factors associated with bovine respiratory disease (BRD) in 136 recently weaned cattle (“weanlings”), 6–12 mo of age, that were submitted for postmortem examination to regional veterinary laboratories in Ireland. A standardized sampling protocol included routine microbiologic investigations as well as polymerase chain reaction and immunohistochemistry. Lungs with histologic lesions were categorized into 1 of 5 morphologic patterns of pneumonia. Fibrinosuppurative bronchopneumonia (49%) and interstitial pneumonia (48%) were the morphologic patterns recorded most frequently. The various morphologic patterns of pulmonary lesions suggest the involvement of variable combinations of initiating and compounding infectious agents that hindered any simple classification of the etiopathogenesis of the pneumonias. Dual infections were detected in 58% of lungs, with Mannheimia haemolytica and Histophilus somni most frequently recorded in concert. M. haemolytica (43%) was the most frequently detected respiratory pathogen; H. somni was also shown to be frequently implicated in pneumonia in this age group of cattle. Bovine parainfluenza virus 3 (BPIV-3) and Bovine respiratory syncytial virus (16% each) were the viral agents detected most frequently. Potential respiratory pathogens (particularly Pasteurella multocida, BPIV-3, and H. somni) were frequently detected (64%) in lungs that had neither gross nor histologic pulmonary lesions, raising questions regarding their role in the pathogenesis of BRD. The breadth of respiratory pathogens detected in bovine lungs by various detection methods highlights the diagnostic value of parallel analyses in respiratory disease postmortem investigation. |
| Databáze: | OpenAIRE |
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