Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder
| Autor: | Xu Liu, Wei-Hai Ye, Zhi-Kun Qiu, Ji-Sheng Chen, Jia Zeng, Wei Xiao, Jia-Li He, Qinghong Fan, Xiaomeng Chai |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Serotonin medicine.medical_specialty Elevated plus maze Corticotropin-Releasing Hormone Prefrontal Cortex Hippocampus Adrenocorticotropic hormone Motor Activity Biochemistry Open field Rats Sprague-Dawley Stress Disorders Post-Traumatic 03 medical and health sciences Cellular and Molecular Neuroscience Corticotropin-releasing hormone chemistry.chemical_compound 0302 clinical medicine Adrenocorticotropic Hormone Glucosides Corticosterone Internal medicine medicine Animals Freezing Reaction Cataleptic Behavior Animal business.industry Hydroxyindoleacetic Acid Paeoniflorin Rats Disease Models Animal Treatment Outcome 030104 developmental biology Endocrinology Anti-Anxiety Agents chemistry Monoterpenes Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Metabolic Brain Disease. 33:1175-1185 |
| ISSN: | 1573-7365 0885-7490 |
| DOI: | 10.1007/s11011-018-0216-4 |
| Popis: | Post-traumatic stress disorder (PTSD) is the serious psychiatric disorder. Paeoniflorin (PF) produces the antidepressant-like properties. However, few studies are concerned about its anti-PTSD-like effects and mechanisms. To investigate these, the single prolonged stress (SPS) model was utilized. PTSD-like behavioral deficits in rats after exposure to SPS were improved by PF (10 and 20 mg/kg, i.p.), evidenced by blocking increased freezing time in contextual fear paradigm (CFP) and increased time and entries in open arms in elevated plus maze (EPM) test without affecting the locomotor activity in open field (OF) test. We also found that increased levels of corticosterone (Cort), corticotropin releasing hormone (CRH) and adrenocorticotropic hormone (ACTH) after exposure to SPS were reversed by PF (10 and 20 mg/kg, i.p.) in serum, respectively. Moreover, the decreased levels of serotonin (5-HT) and 5-Hydroxyindoleacetic acid (5-HIAA) in prefrontal cortex and hippocampus were reversed by PF (10 and 20 mg/kg, i.p.), respectively. In summary, the anti-PTSD-like activities of PF were associated with the modulation of HPA axis and 5-HT system activation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink