Control of coronavirus infection through plasmacytoid dendritic-cell–derived type I interferon
| Autor: | Luisa Cervantes-Barragan, Karl S. Lang, Friedemann Weber, Martin Spiegel, Shizuo Akira, Burkhard Ludewig, Volker Thiel, Roland Züst |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
viruses
Immunology MHV indicates mouse hepatitis virusSARS severe acute respiratory syndromepDCs plasmacytoid dendritic cellscDCs conventional dendritic cells Plasmacytoid dendritic cell medicine.disease_cause Virus Replication Biochemistry Mice Mouse hepatitis virus Interferon medicine Animals Humans Coronavirus Phagocytes Membrane Glycoproteins biology virus diseases Interferon-alpha RNA virus hemic and immune systems Cell Biology Hematology TLR7 Dendritic Cells biology.organism_classification Virology Viral replication Severe acute respiratory syndrome-related coronavirus Toll-Like Receptor 7 Interferon Type I Coronavirus Infections Interferon type I medicine.drug |
| Zdroj: | Blood |
| ISSN: | 1528-0020 0006-4971 |
| Popis: | This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-α production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections. |
| Databáze: | OpenAIRE |
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