Promising approaches for treatment and prevention of viral respiratory illnesses
| Autor: | Nikolaos G. Papadopoulos, Olympia Vangelatou, Paraskevi Xepapadaki, Nikolaos A. Kitsioulis, Spyridon Megremis, Peter W. West |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
SARS Severe acute respiratory syndrome Rhinovirus natural products respiratory syncytial virus viruses vRTI Viral respiratory tract infection medicine.disease_cause SPM Specialized proresolving lipid mediator Viral Respiratory Tract Infection vaccine Immunology and Allergy VLP Virus-like particle PIV Parainfluenza Virus Respiratory Tract Infections Respiratory tract infections biology Neuraminidase inhibitor Viral Vaccine public health Common cold Orthomyxoviridae antiviral Respiratory Syncytial Viruses 3. Good health Virus Diseases RSV Respiratory syncytial virus bronchiolitis NAI Neuraminidase inhibitor Immunotherapy TLR Toll-like receptor medicine.drug_class ICAM-1 Intercellular adhesion molecule 1 Immunology monoclonal COPD Chronic obstructive pulmonary disease RTI Respiratory tract infection Mass Vaccination Article 03 medical and health sciences medicine Animals Humans IFV Influenza virus Viral Vaccines medicine.disease biology.organism_classification common cold Influenza 030104 developmental biology Bronchiolitis HA Hemagglutinin |
| Zdroj: | Megremis, S, Papadopoulos, N, Kitsioulis, N A, Vangelatou, O, West, P & Xepapadaki, P 2017, ' Promising approaches for treatment and prevention of viral respiratory illnesses ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2017.07.001 The Journal of Allergy and Clinical Immunology |
| DOI: | 10.1016/j.jaci.2017.07.001 |
| Popis: | Viral respiratory tract infections are the most common human ailments, leading to enormous health and economic burden. Hundreds of viral species and subtypes have been associated with these conditions, with influenza viruses, respiratory syncytial virus, and rhinoviruses being the most frequent and with the highest burden. When considering prevention or treatment of viral respiratory tract infections, potential targets include the causative pathogens themselves but also the immune response, disease transmission, or even just the symptoms. Strategies targeting all these aspects are developing concurrently, and several novel and promising approaches are emerging. In this perspective we overview the entire range of options and highlight some of the most promising approaches, including new antiviral agents, symptomatic or immunomodulatory drugs, the re-emergence of natural remedies, and vaccines and public health policies toward prevention. Wide-scale prevention through immunization appears to be within reach for respiratory syncytial virus and promising for influenza virus, whereas additional effort is needed in regard to rhinovirus, as well as other respiratory tract viruses. |
| Databáze: | OpenAIRE |
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