Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay
| Autor: | Agnès Lehuen, Roberto Mallone, Marc Dalod, Lucie Beaudoin, Julien Diana, Anna Tafuri, Vedran Brezar, Christian Boitard, Andrew L. Mellor, Matthias von Herrath |
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| Přispěvatelé: | Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Paris 5 (UPD5), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Medical College of Georgia, Immunotherapy Center, Immunité et cancer (U932), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), La Jolla Institute for Immunology [La Jolla, CA, États-Unis], Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), CHU Cochin [AP-HP], Université Paris Descartes - Paris 5 (UPD5)-Institut Curie-Institut National de la Santé et de la Recherche Médicale (INSERM), La Jolla Institute for Allergy and Immunology (LIA), La Jolla Institute for Allergy & Immunology, Université Paris Descartes - Paris 5 ( UPD5 ), Centre d'Immunologie de Marseille - Luminy ( CIML ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Immunité et cancer ( U932 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut Curie-Institut National de la Santé et de la Recherche Médicale ( INSERM ), La Jolla Institute for Allergy and Immunology ( LIA ) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
MESH: Interleukin-10
endocrine system diseases Programmed Cell Death 1 Receptor MESH: Membrane Glycoproteins MESH : Membrane Glycoproteins MESH: Lymph Nodes Cell Communication CD8-Positive T-Lymphocytes Lymphocyte Activation T-Lymphocytes Regulatory B7-H1 Antigen MESH : Diabetes Mellitus Type 1 MESH : T-Lymphocytes Regulatory Interleukin 21 Mice 0302 clinical medicine Transforming Growth Factor beta immune system diseases [ SDV.IMM ] Life Sciences [q-bio]/Immunology Immunology and Allergy Cytotoxic T cell MESH: Animals IL-2 receptor MESH : Antigens CD80 MESH : Lymph Nodes 0303 health sciences Membrane Glycoproteins MESH: Dendritic Cells MESH : Peptides MESH: Peptides FOXP3 hemic and immune systems MESH : CD8-Positive T-Lymphocytes Natural killer T cell MESH: CD8-Positive T-Lymphocytes 3. Good health Interleukin-10 MESH: Virus Diseases medicine.anatomical_structure Virus Diseases Antigens Surface B7-1 Antigen [SDV.IMM]Life Sciences [q-bio]/Immunology MESH: Diabetes Mellitus Type 1 MESH : Apoptosis Regulatory Proteins MESH : Antigens Surface endocrine system MESH : Cell Communication MESH: Antigens Surface T cell Immunology macromolecular substances Biology Article 03 medical and health sciences Islets of Langerhans MESH: Antigens CD80 MESH : Interleukin-10 MESH : Mice MESH: Cell Communication medicine Animals MESH : Islets of Langerhans Antigen-presenting cell MESH: Lymphocyte Activation MESH: Mice MESH : Lymphocyte Activation MESH: Transforming Growth Factor beta 030304 developmental biology MESH: Apoptosis Regulatory Proteins MESH: T-Lymphocytes Regulatory MESH: Islets of Langerhans Dendritic cell Dendritic Cells MESH : Virus Diseases MESH : Natural Killer T-Cells MESH : Transforming Growth Factor beta Diabetes Mellitus Type 1 MESH: Natural Killer T-Cells MESH : Dendritic Cells Natural Killer T-Cells MESH : Animals Lymph Nodes Apoptosis Regulatory Proteins Peptides 030215 immunology |
| Zdroj: | Journal of Experimental Medicine Journal of Experimental Medicine, Rockefeller University Press, 2011, 208 (4), pp.729-45. ⟨10.1084/jem.20101692⟩ The Journal of Experimental Medecine The Journal of Experimental Medecine, The Rockefeller University Press, 2011, 208 (4), pp.729-45. ⟨10.1084/jem.20101692⟩ Journal of Experimental Medicine, 2011, 208 (4), pp.729-45. ⟨10.1084/jem.20101692⟩ The Journal of Experimental Medicine The Journal of Experimental Medecine, The Rockefeller University Press, 2011, 208 (4), pp.729-45. 〈10.1084/jem.20101692〉 |
| ISSN: | 0022-1007 1540-9538 |
| DOI: | 10.1084/jem.20101692⟩ |
| Popis: | iNKT cell and pDC cross talk prevents type 1 diabetes by inducing T reg cells in the pancreatic lymph node during viral infection. Type 1 diabetes (T1D) is an autoimmune disease resulting from T cell–mediated destruction of insulin-producing β cells, and viral infections can prevent the onset of disease. Invariant natural killer T cells (iNKT cells) exert a regulatory role in T1D by inhibiting autoimmune T cell responses. As iNKT cell–plasmacytoid dendritic cell (pDC) cooperation controls viral replication in the pancreatic islets, we investigated whether this cellular cross talk could interfere with T1D development during viral infection. Using both virus-induced and spontaneous mouse models of T1D, we show that upon viral infection, iNKT cells induce TGF-β–producing pDCs in the pancreatic lymph nodes (LNs). These tolerogenic pDCs convert naive anti-islet T cells into Foxp3+ CD4+ regulatory T cells (T reg cells) in pancreatic LNs. T reg cells are then recruited into the pancreatic islets where they produce TGF-β, which dampens the activity of viral- and islet-specific CD8+ T cells, thereby preventing T1D development in both T1D models. These findings reveal a crucial cooperation between iNKT cells, pDCs, and T reg cells for prevention of T1D by viral infection. |
| Databáze: | OpenAIRE |
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