The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3beta in the developing murine liver, intestine and pancreas
| Autor: | Luc Bélanger, Luc Galarneau, Francisco M. Rausa, Robert H. Costa |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Embryology
medicine.medical_specialty animal structures Carcinoma Hepatocellular Morphogenesis Receptors Cytoplasmic and Nuclear In situ hybridization Biology Mice stomatognathic system Internal medicine medicine Tumor Cells Cultured Animals Yolk sac Pancreas Embryogenesis Endoderm Neural crest Gene Expression Regulation Developmental Nuclear Proteins Cell biology DNA-Binding Proteins Intestines Hepatocyte nuclear factors Endocrinology medicine.anatomical_structure Liver embryonic structures Hepatocyte Nuclear Factor 3-beta Developmental Biology Transcription Factors |
| Zdroj: | Mechanisms of development. 89(1-2) |
| ISSN: | 0925-4773 |
| Popis: | During organogenesis, the winged helix hepatocyte nuclear factor 3 β (HNF-3 β ) protein participates in regulating gene transcription in the developing esophagus, trachea, liver, lung, pancreas, and intestine. Hepatoma cell transfection studies identified a critical HNF-3 β promoter factor, named UF2-H3 β , and here, we demonstrate that UF2-H3 β is identical to the fetoprotein transcription factor (FTF). In situ hybridization studies of mouse embryos demonstrate that FTF expression initiates in the foregut endoderm during liver and pancreatic morphogenesis (day 9) and that earlier expression of FTF is observed in the yolk sac endoderm, branchial arch and neural crest cells (day 8). Abundant FTF hybridization signals are observed throughout morphogenesis of the liver, pancreas, and intestine and its expression continues in the epithelial cells of these adult organs. In day 17 mouse embryos and adult pancreas, however, expression of FTF becomes restricted to the exocrine acinar and ductal epithelial cells. |
| Databáze: | OpenAIRE |
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