Myocardial phenotypic changes in Na+, K+ ATPase in left ventricular hypertrophy: pharmacological consequences
| Autor: | D. Charlemagne, Bernard Swynghedauw |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Gene isoform
medicine.medical_specialty Cardiotonic Agents ATPase Sodium Protein subunit chemistry.chemical_element Digitalis Left ventricular hypertrophy Ouabain Internal medicine Medicine Animals Humans Glycosides Na+/K+-ATPase biology business.industry Myocardium Digitalis Glycosides biology.organism_classification medicine.disease Rats Endocrinology Phenotype chemistry biology.protein Calcium Hypertrophy Left Ventricular Sodium-Potassium-Exchanging ATPase Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | European heart journal. 16 |
| ISSN: | 0195-668X |
| Popis: | Cardiac adaptation to permanent overload induces several phenotypic changes which finally result in a system which works more economically, together with a slower Vmax. The molecular target of digitalis is the NA+, K+ ATPase, which is a polymorphic molecule. We have recently demonstrated that during cardiac hypertrophy this target is modified and that a shift occurs in the alpha 1 subunit, from the normally present alpha 2 isosubunit to alpha 3, which is a fetal isoform with a lower affinity for sodium and a higher affinity for ouabain. Such a shift explains why, in rat cardiac hypertrophy ouabain is less toxic than normal and is released from its target more slowly. It may also explain at least in part the discrepancies observed in clinical trials on the efficacy of digitalis. |
| Databáze: | OpenAIRE |
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