Fetal/neonatal alloimmune thrombocytopenia: a systematic review of impact of HLA-DRB3*01:01 on fetal/neonatal outcome
| Autor: | Michael F. Murphy, Greg Ryan, Lani Lieberman, Tamam Bakchoul, Helen Savoia, Dick Oepkes, Denise Landry, Andreas Greinacher, Jillian M. Baker, James B. Bussel, Cécile Kaplan, Stacy Corke, Shoma Baidya, Edwin Massey, Mette Kjaer, Jens Kjeldsen-Kragh, Dean Fergusson, Gerald Bertrand, Donald M. Arnold, Nadine Shehata, Heather Hume |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Population 030204 cardiovascular system & hematology Neonatal Thrombocytopenia 03 medical and health sciences 0302 clinical medicine Fetus medicine Humans Prospective Studies education Prospective cohort study Child Retrospective Studies education.field_of_study biology Obstetrics business.industry Infant Newborn Retrospective cohort study Hematology Odds ratio medicine.disease Platelets and Thrombopoiesis Confidence interval Human platelet antigen Thrombocytopenia Neonatal Alloimmune 030220 oncology & carcinogenesis Neonatal alloimmune thrombocytopenia biology.protein Female business HLA-DRB3 Chains |
| Zdroj: | Blood Adv |
| ISSN: | 2473-9537 |
| Popis: | The most common, severe cases of fetal and neonatal alloimmune thrombocytopenia among whites are caused by antibodies against human platelet antigen 1a (HPA-1a). The aims of this systematic review and meta-analysis are to determine the association between maternal HLA-DRB3*01:01 and: (1) HPA-1a-alloimmunization and (2) neonatal outcome in children born of HPA-1a-immunized women. A systematic literature search identified 4 prospective and 8 retrospective studies. Data were combined across studies to estimate pooled odds ratios (ORs) and the associated 95% confidence intervals (CIs). The population represented by the prospective studies was more than 150 000. In the prospective studies, there were 64 severely thrombocytopenic newborns (platelet count |
| Databáze: | OpenAIRE |
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