Case series of elderly patients with scabies topically applied with ivermectin via whole‐body bathing
| Autor: | Kuniko Makigami, Atsushi Miyajima, Machi Koshino, Rie Ozeki, Masayo Komoda, Mizuki Yamada, Shunta Akutsu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cure rate Bathing Dermatology Scabies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Ivermectin Humans Medicine Blood test Adverse effect Aged medicine.diagnostic_test urogenital system business.industry Baths General Medicine medicine.disease 030220 oncology & carcinogenesis embryonic structures business Whole body Skin lesion medicine.drug |
| Zdroj: | The Journal of Dermatology. 48:559-563 |
| ISSN: | 1346-8138 0385-2407 |
| DOI: | 10.1111/1346-8138.15746 |
| Popis: | As a novel method of ivermectin (IVM) administration for the treatment of scabies, we devised a whole-body bathing (WBB), in which patients are immersed in a fluid that contains IVM. A multi-institutional trial for elderly patients with scabies was conducted to investigate the efficacy and safety of IVM-WBB. Seven elderly patients with scabies were enrolled and received IVM-WBB up to four times at 1-week interval. The cure for scabies was defined as the absence of mites in two consecutive microscopic or dermoscopic examinations at weekly intervals and the absence of new skin lesions indicative of scabies. Consequently, the cure rate on day 22, the primary end-point, was 71.4%, and all patients had been cured until day 29. Additionally, neither significant adverse events nor clinically problematic abnormal blood test values were obtained. Furthermore, no IVM was detected in the optional plasma (five cases) collected for IVM measurement after bathing. These results suggest that IVM-WBB was effective to treat scabies, causing no serious adverse events and with a very low internal exposure of IVM. |
| Databáze: | OpenAIRE |
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