Alzheimer’s Disease: Pathogenesis and Therapeutic Interventions
| Autor: | Chinazom Precious Agbo, Martins Obinna Ogugofor, John Onyebuchi Ogbodo, Chandrashekhar D. Upasani, Stella Amarachi Ihim, Kenneth Chibuike Brendan, UO Njoku, Aman Upaganlawar, Adaeze Chidiebere Echezona, Simeon Ikechukwu Egba |
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| Rok vydání: | 2022 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Superparamagnetic iron oxide nanoparticles Mediterranean diet business.industry Psychological intervention Early detection Disease Disease pathogenesis Diet Mediterranean medicine.disease Therapeutic approach Early Diagnosis Alzheimer Disease Pediatrics Perinatology and Child Health medicine Humans Dementia Intensive care medicine business |
| Zdroj: | Current Aging Science. 15:2-25 |
| ISSN: | 1874-6098 |
| Popis: | Background: Alzheimer’s Disease (AD) is the most common cause of dementia. Genetics, excessive exposure to environmental pollutants, as well as unhealthy lifestyle practices are often linked to the development of AD. No therapeutic approach has achieved complete success in treating AD; however, early detection and management with appropriate drugs are key to improving prognosis. Interventions: The pathogenesis of AD was extensively discussed in order to understand the reasons for the interventions suggested. The interventions reviewed include the use of different therapeutic agents and approaches, gene therapy, adherence to healthy dietary plans (Mediterranean diet, Okinawan diet and MIND diet), as well as the use of medicinal plants. The potential of nanotechnology as a multidisciplinary and interdisciplinary approach in the design of nano-formulations of AD drugs and the use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) as theranostic tools for early detection of Alzheimer’s disease were also discussed. |
| Databáze: | OpenAIRE |
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