Angiogenic heparin-mimetic peptide nanofiber gel improves regenerative healing of acute wounds
| Autor: | Taner Ozgurtas, Ayse B. Tekinay, Doğan Alhan, Rashad Mammadov, Serdar Ozturk, Fatih Yesildal, Gozde Uzunalli, Mustafa O. Guler |
|---|---|
| Přispěvatelé: | Güler, Mustafa O. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Heparin mimetic peptide nanofiber Unclassified drug Angiogenesis 02 engineering and technology Pharmacology Animal tissue In vivo study Wound healing promoting agent Heparin-mimetic peptide nanofiber Peptidomimetic agent Priority journal Gel integumentary system Granulation tissue Heparin Self-assembly 021001 nanoscience & nanotechnology medicine.anatomical_structure Peptide mimetic Blood vessel Female Skin appendage 0210 nano-technology Amphophile medicine.drug medicine.medical_specialty Histology Biomedical Engineering Wound healing Wound closure Article Scar formation Biomaterials 03 medical and health sciences medicine Animal model Animal experiment Epithelization business.industry Skin injury Vascularization Nanofiber Nonhuman Surgery 030104 developmental biology Rat business Controlled study |
| Zdroj: | ACS Biomaterials Science and Engineering |
| Popis: | Wound repair in adult mammals typically ends with the formation of a scar, which prevents HI restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of major wound injuries requires therapeutic approaches that can enhance the healing process via overcoming mechanical and biochemical problems. In this study, we showed that self-assembled heparin-mimetic peptide nanofiber gel was an effective bioactive wound dressing for the rapid and functional repair of full-thickness excisional wounds in the rat model. The bioactive gel-treated wounds exhibited increased angiogenesis (p < 0.05), re-epithelization (p < 0.05), skin appendage 'formation, and granulation tissue organization (p < 0.05) compared to sucrose treated samples. Increased blood vessel numbers in the gel-treated wounds on day 7 suggest that angiogenesis played a key role in improvement of tissue healing in bioactive gel-treated wounds. Overall, the angiogenic heparin-mimetic peptide nanofiber gel is a promising platform for enhancing the scar-free recovery of acute wounds. |
| Databáze: | OpenAIRE |
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