Testicular macrophages: development and function in health and disease
| Autor: | Sudhanshu Bhushan, Andreas Meinhardt, Nathalie Dejucq-Rainsford |
|---|---|
| Přispěvatelé: | Justus-Liebig-Universität Gießen = Justus Liebig University (JLU), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Deutsche Forschungsgemeinschaft, DFG: BH 93/1-4, GRK 1871/2, Chard-Hutchinson, Xavier |
| Rok vydání: | 2022 |
| Předmět: |
Male
Mammals education.field_of_study Macrophages [SDV]Life Sciences [q-bio] Immunology Cell Population Disease Biology medicine.disease Phenotype Virus Male infertility [SDV] Life Sciences [q-bio] medicine.anatomical_structure Immune system Testis medicine Animals Humans Immunology and Allergy education Function (biology) |
| Zdroj: | Trends in Immunology Trends in Immunology, 2022, 43 (1), pp.51-62. ⟨10.1016/j.it.2021.11.003⟩ |
| ISSN: | 1471-4906 |
| DOI: | 10.1016/j.it.2021.11.003 |
| Popis: | International audience; Macrophages comprise a heterogeneous immune cell population and display niche-specific phenotypes and functions in almost all organs. Testicular macrophages (TMs) perform essential immune and non-immune functions in the mammalian male gonads. Here, we discuss the most recent findings on TM ontogeny, heterogeneity, and function under steady state and inflammatory conditions. We also highlight new discoveries regarding the functions of macrophages during bacterial and viral infections of the testes and how macrophages may indirectly help the establishment of a reservoir through virus seeding. Understanding TM function and macrophage-related mechanisms of disease might assist in developing new opportunities for intervention in male infertility. © 2021 Elsevier Ltd |
| Databáze: | OpenAIRE |
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