Distinct claudin expression characterizesBRCA1-related breast cancer
| Autor: | Elsken van der Wall, Marise R. Heerma van Voss, Joost Bart, Paul J. van Diest, Petra van der Groep, Yvonne H. C. M. Smolders |
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| Přispěvatelé: | Targeted Gynaecologic Oncology (TARGON) |
| Rok vydání: | 2014 |
| Předmět: |
Oncology
medicine.medical_specialty Histology endocrine system diseases FEATURES Genes BRCA1 Breast Neoplasms Biology urologic and male genital diseases medicine.disease_cause digestive system Pathology and Forensic Medicine Germline mutation Breast cancer Internal medicine Gene expression Biomarkers Tumor medicine Humans CLOSTRIDIUM-PERFRINGENS ENTEROTOXIN skin and connective tissue diseases Claudin GENE-EXPRESSION MESENCHYMAL TRANSITION Mutation familial breast cancer Carcinoma in situ LOW INTRINSIC SUBTYPE TIGHT JUNCTION PROTEIN Cancer General Medicine MAMMARY EPITHELIAL-CELLS BRCA1 medicine.disease Immunohistochemistry digestive system diseases DIFFERENTIATION CARCINOMA IN-SITU Claudins Female BRCA1 protein |
| Zdroj: | Histopathology, 65(6), 814-827. Wiley |
| ISSN: | 0309-0167 |
| DOI: | 10.1111/his.12490 |
| Popis: | AimsMembers of the claudin family are involved in cancer progression and are differentially expressed in subtypes of breast cancer. Breast cancers in BRCA1 germ line mutation carriers have distinct clinicopathological characteristics. Biomarkers that discriminate between BRCA1-related and sporadic breast cancer cases are needed to improve early identification of mutation carriers. In this study we evaluated protein expression of five major claudins in BRCA1-related breast cancers in comparison with sporadic controls.Methods and resultsForty breast cancers in BRCA1 mutation carriers and 40 age-matched sporadic breast cancers were immunohistochemically stained for claudins 1, 3, 4, 6 and 7. Total intratumoural expression levels were compared to those in the surrounding normal tissue. In addition, subcellular claudin expression was scored. Higher overexpression rates were observed for all five claudins in BRCA1-related breast cancers when compared to sporadic controls. In multivariate analysis, overexpression of claudin 3, 4, and 7 was mainly dependent on ER-status, whereas overexpression of claudin 6 and high membranous expression of claudin 1 were independent of other characteristics.ConclusionsBRCA1-related breast cancers are characterized by frequent overexpression of claudins. Especially claudin 1 and 6 expression may help to discriminate mutation carriers from sporadic breast cancer cases. |
| Databáze: | OpenAIRE |
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