Transcriptional adaptation in Caenorhabditis elegans
| Autor: | Zacharias Kontarakis, Amr M. Saadeldein, Nicholas Retzer, Ann M. Wehman, Oleg O. Tolstenkov, Alexander Gottschalk, Vahan Serobyan, Mohamed A. El-Brolosy, Didier Y.R. Stainier, Jordan M. Welker |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Small RNA
QH301-705.5 Science Mutant General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine mRNA decay RNA interference Gene expression small RNA Biology (General) Zebrafish Caenorhabditis elegans 030304 developmental biology 0303 health sciences General Immunology and Microbiology biology General Neuroscience General Medicine Argonaute biology.organism_classification Cell biology transcriptional adaptation RNAi C. elegans biology.protein Medicine 030217 neurology & neurosurgery Dicer |
| Zdroj: | eLIFE eLife, Vol 9 (2020) eLife, 9 eLife |
| ISSN: | 2050-084X |
| DOI: | 10.3929/ethz-b-000396015 |
| Popis: | Transcriptional adaptation is a recently described phenomenon by which a mutation in one gene leads to the transcriptional modulation of related genes, termed adapting genes. At the molecular level, it has been proposed that the mutant mRNA, rather than the loss of protein function, activates this response. While several examples of transcriptional adaptation have been reported in zebrafish embryos and in mouse cell lines, it is not known whether this phenomenon is observed across metazoans. Here we report transcriptional adaptation in C. elegans, and find that this process requires factors involved in mutant mRNA decay, as in zebrafish and mouse. We further uncover a requirement for Argonaute proteins and Dicer, factors involved in small RNA maturation and transport into the nucleus. Altogether, these results provide evidence for transcriptional adaptation in C. elegans, a powerful model to further investigate underlying molecular mechanisms. eLife, 9 ISSN:2050-084X |
| Databáze: | OpenAIRE |
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