Advances in the Chemical Biology of Desferrioxamine B
| Autor: | Thomas J. Telfer, Michael P. Gotsbacher, Tomas Richardson-Sanchez, Rachel Codd |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Streptomyces pilosus Metabolite Chemical biology Siderophores Chemistry Techniques Synthetic Deferoxamine Biology Crystallography X-Ray Iron Chelating Agents Biochemistry 03 medical and health sciences chemistry.chemical_compound Humans Fluorescent Dyes Hydroxamic acid Hydrolysis General Medicine Anti-Bacterial Agents 3. Good health Hemoglobin disorders 030104 developmental biology chemistry Positron-Emission Tomography Molecular Medicine Zirconium |
| Zdroj: | ACS Chemical Biology. 13:11-25 |
| ISSN: | 1554-8937 1554-8929 |
| DOI: | 10.1021/acschembio.7b00851 |
| Popis: | Desferrioxamine B (DFOB) was discovered in the late 1950s as a hydroxamic acid metabolite of the soil bacterium Streptomyces pilosus. The exquisite affinity of DFOB for Fe(III) identified its potential for removing excess iron from patients with transfusion-dependent hemoglobin disorders. Many studies have used semisynthetic chemistry to produce DFOB adducts with new properties and broad-ranging functions. More recent approaches in chemical biology have revealed some nuances of DFOB biosynthesis and discovered new DFOB-derived drugs and radiometal imaging agents. The current and potential applications of DFOB continue to inspire a rich body of chemical biology research focused on this bacterial metabolite. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|