Critical In Vitro Characterization Methods of Lipid-Based Formulations for Oral Delivery: a Comprehensive Review
| Autor: | Nitin K. Swarnakar, Natarajan Venkatesan, Guru V. Betageri |
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| Rok vydání: | 2018 |
| Předmět: |
Drug
media_common.quotation_subject Chemistry Pharmaceutical Drug Compounding Pharmaceutical Science Administration Oral 02 engineering and technology Aquatic Science 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Characterization methods In vivo Drug Discovery Animals Solubility Particle Size Dissolution Ecology Evolution Behavior and Systematics Phospholipids media_common Chromatography Ecology Chemistry General Medicine 021001 nanoscience & nanotechnology Lipids In vitro Bioavailability lipids (amino acids peptides and proteins) 0210 nano-technology Digestion Agronomy and Crop Science |
| Zdroj: | AAPS PharmSciTech. 20(1) |
| ISSN: | 1530-9932 |
| Popis: | Lipids have been extensively used in formulations to enhance dissolution and bioavailability of poorly water-soluble as well as water-soluble drug molecules. The digestion of lipid-based formulations, in the presence of bile salts, phospholipids, and cholesterol, changes the lipid composition in vivo, resulting in the formation of different colloidal phases in the intestine. Therefore, in vitro characterization and evaluation of such formulations are critical in developing a successful formulation. This review covers comprehensive discussion on in vitro characterization techniques such as solubility, drug entrapment, thermal characterization, dissolution, and digestion of lipid-based formulations. |
| Databáze: | OpenAIRE |
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