Dysregulation of Limbic and Auditory Networks in Tinnitus
| Autor: | Laurent Renier, Mark A. Chevillet, Hung J. Kim, Amber M. Leaver, Josef P. Rauschecker, Susan Morgan |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Neuroscience(all) Auditory area Ventromedial prefrontal cortex Chronic tinnitus Prefrontal Cortex Nucleus accumbens Article Nucleus Accumbens Tinnitus 03 medical and health sciences 0302 clinical medicine Limbic system mental disorders Limbic System otorhinolaryngologic diseases medicine Humans Auditory system 030304 developmental biology Auditory Cortex 0303 health sciences medicine.diagnostic_test General Neuroscience Middle Aged Magnetic Resonance Imaging medicine.anatomical_structure nervous system Case-Control Studies Female medicine.symptom Functional magnetic resonance imaging Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron. 69:33-43 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2010.12.002 |
| Popis: | SummaryTinnitus is a common disorder characterized by ringing in the ear in the absence of sound. Converging evidence suggests that tinnitus pathophysiology involves damage to peripheral and/or central auditory pathways. However, whether auditory system dysfunction is sufficient to explain chronic tinnitus is unclear, especially in light of evidence implicating other networks, including the limbic system. Using functional magnetic resonance imaging and voxel-based morphometry, we assessed tinnitus-related functional and anatomical anomalies in auditory and limbic networks. Moderate hyperactivity was present in the primary and posterior auditory cortices of tinnitus patients. However, the nucleus accumbens exhibited the greatest degree of hyperactivity, specifically to sounds frequency-matched to patients' tinnitus. Complementary structural differences were identified in ventromedial prefrontal cortex, another limbic structure heavily connected to the nucleus accumbens. Furthermore, tinnitus-related anomalies were intercorrelated in the two limbic regions and between limbic and primary auditory areas, indicating the importance of auditory-limbic interactions in tinnitus. |
| Databáze: | OpenAIRE |
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