Diagnostic and Prognostic Value of pH- and Oxygen-Sensitive Magnetic Resonance Imaging in Glioma: A Retrospective Study

Autor:	Jingwen Yao, Akifumi Hagiwara, Talia C. Oughourlian, Chencai Wang, Catalina Raymond, Whitney B. Pope, Noriko Salamon, Albert Lai, Matthew Ji, Phioanh L. Nghiemphu, Linda M. Liau, Timothy F. Cloughesy, Benjamin M. Ellingson
Rok vydání:	2022
Předmět:	screening and diagnosis Cancer Research genotype Oncology and Carcinogenesis Neurosciences multiparametric MRI glioma survival analysis tumor microenvironment Brain Disorders Brain Cancer Detection Rare Diseases Oncology Clinical Research Biomedical Imaging Cancer 4.2 Evaluation of markers and technologies
Zdroj:	Cancers; Volume 14; Issue 10; Pages: 2520 Cancers, vol 14, iss 10
ISSN:	2072-6694
Popis:	Characterization of hypoxia and tissue acidosis could advance the understanding of glioma biology and improve patient management. In this study, we evaluated the ability of a pH- and oxygen-sensitive magnetic resonance imaging (MRI) technique to differentiate glioma genotypes, including isocitrate dehydrogenase (IDH) mutation, 1p/19q co-deletion, and epidermal growth factor receptor (EGFR) amplification, and investigated its prognostic value. A total of 159 adult glioma patients were scanned with pH- and oxygen-sensitive MRI at 3T. We quantified the pH-sensitive measure of magnetization transfer ratio asymmetry (MTRasym) and oxygen-sensitive measure of R2’ within the tumor region-of-interest. IDH mutant gliomas showed significantly lower MTRasym × R2’ (p < 0.001), which differentiated IDH mutation status with sensitivity and specificity of 90.0% and 71.9%. Within IDH mutants, 1p/19q codeletion was associated with lower tumor acidity (p < 0.0001, sensitivity 76.9%, specificity 91.3%), while IDH wild-type, EGFR-amplified gliomas were more hypoxic (R2’ p = 0.024, sensitivity 66.7%, specificity 76.9%). Both R2’ and MTRasym × R2’ were significantly associated with patient overall survival (R2’: p = 0.045; MTRasym × R2’: p = 0.002) and progression-free survival (R2’: p = 0.010; MTRasym × R2’: p < 0.0001), independent of patient age, treatment status, and IDH status. The pH- and oxygen-sensitive MRI is a clinically feasible and potentially valuable imaging technique for distinguishing glioma subtypes and providing additional prognostic value to clinical practice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb38bfbd14c4fb9c68e1d3521bce334d https://pubmed.ncbi.nlm.nih.gov/35626127 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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