Effect of insulin analogues on frequency of non-severe hypoglycaemia in patients with type 1 diabetes prone to severe hypoglycaemia: The HypoAna trial

Autor: Lise Tarnow, Ulrik Pedersen-Bjergaard, Henning Beck-Nielsen, Birger Thorsteinsson, Peter Lommer Kristensen, Tonny Jensen, Hans Perrild, Kirsten Nørgaard, Rikke Mette Agesen, Jens Sandahl Christiansen, Philip Hougaard, H. H. Parving
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Blood Glucose
Relative risk reduction
Nocturnal hypoglycaemia
Male
Pediatrics
endocrine system diseases
Endocrinology
Diabetes and Metabolism
medicine.medical_treatment
Insulin
Isophane
Severity of Illness Index
law.invention
Non-severe hypoglycaemia
0302 clinical medicine
Endocrinology
Insulin Detemir
Randomized controlled trial
law
Insulin
Medicine
030212 general & internal medicine
Cross-Over Studies
Incidence
Absolute risk reduction
General Medicine
Middle Aged
Type 1 diabetes
Female
Disease Susceptibility
medicine.symptom
hormones
hormone substitutes
and hormone antagonists
Adult
medicine.medical_specialty
The HypoAna trial
030209 endocrinology & metabolism
macromolecular substances
Hypoglycemia/chemically induced
Asymptomatic
Insulin
Isophane/administration & dosage
03 medical and health sciences
Blood Glucose/drug effects
Diabetes mellitus
Internal Medicine
Hypoglycemic Agents
Humans
Insulin Aspart/administration & dosage
Insulin Aspart
Aged
Insulin analogues
business.industry
nutritional and metabolic diseases
Diabetes Mellitus
Type 1/blood
medicine.disease
Hypoglycemic Agents/administration & dosage
Crossover study
Hypoglycemia
Surgery
Diabetes Mellitus
Type 1
Insulin Detemir/administration & dosage
business
Insulin/administration & dosage
Zdroj: Agesen, R M, Kristensen, P L, Beck-Nielsen, H, Nørgaard, K, Perrild, H, Christiansen, J S, Jensen, T, Hougaard, P, Parving, H H, Thorsteinsson, B, Tarnow, L & Pedersen-Bjergaard, U 2016, ' Effect of insulin analogues on frequency of non-severe hypoglycaemia in patients with type 1 diabetes prone to severe hypoglycaemia: The HypoAna trial ', Diabetes & Metabolism, vol. 42, no. 4, pp. 249-55 . https://doi.org/10.1016/j.diabet.2016.03.001
Agesen, R M, Kristensen, P L, Beck-Nielsen, H, Nørgaard, K, Perrild, H, Christiansen, J S, Jensen, T, Hougaard, P, Parving, H H, Thorsteinsson, B, Tarnow, L & Pedersen-Bjergaard, U 2016, ' Effect of insulin analogues on frequency of non-severe hypoglycaemia in patients with type 1 diabetes prone to severe hypoglycaemia : The HypoAna trial ', Diabetes & Metabolism, vol. 42, no. 4, pp. 249-255 . https://doi.org/10.1016/j.diabet.2016.03.001
Europe PubMed Central
Popis: AIM: Insulin analogues reduce the risk of hypoglycaemia compared with human insulin in patients with type 1 diabetes (T1D) and minor hypoglycaemia problems. The HypoAna trial showed that, in patients with recurrent severe hypoglycaemia, treatment based on insulin analogues reduces the risk of severe hypoglycaemia. The present study aims to assess whether this also applies to non-severe hypoglycaemia events during the day and at night.METHODS: This 2-year investigator-initiated multicentre, prospective, randomized, open, blinded endpoint (PROBE) trial involved patients with T1D and at least two episodes of severe hypoglycaemia during the previous year. Using a balanced crossover design, patients were randomized to basal-bolus therapy based on analogue (detemir/aspart) or human (NPH/regular) insulins. A total of 114 participants were included. Endpoints were the number of severe hypoglycaemic events and non-severe events, including documented symptomatic and asymptomatic episodes occurring during the day and at night (ClinicalTrials.gov number: NCT00346996).RESULTS: Analogue-based treatment resulted in a 6% (2-10%; P=0.0025) overall relative risk reduction of non-severe hypoglycaemia. This was due to a 39% (32-46%; PCONCLUSION: In T1D patients prone to severe hypoglycaemia, treatment with analogue insulin reduced the risk of non-severe nocturnal hypoglycaemia compared with human insulin.
Databáze: OpenAIRE
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