Bone mass and structure in adolescents with type 1 diabetes compared to healthy peers
| Autor: | M. K. Salo, Harri Sievänen, Marja-Terttu Saha, S. Tulokas, Heikki Saha |
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| Rok vydání: | 2008 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty Pediatrics Bone density Adolescent Endocrinology Diabetes and Metabolism Osteoporosis Absorptiometry Photon Sex Factors Bone Density Diabetes mellitus Internal medicine medicine Humans Child Type 1 diabetes Lumbar Vertebrae Anthropometry Tibia business.industry Femur Neck Case-control study musculoskeletal system medicine.disease Rheumatology Radius Endocrinology Diabetes Mellitus Type 1 Case-Control Studies Orthopedic surgery Female business Tomography X-Ray Computed human activities Bone mass |
| Zdroj: | Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. 20(8) |
| ISSN: | 1433-2965 |
| Popis: | We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with reduced bone mass and smaller bones. The diabetes-associated deficits seemed to concern male adolescents more than females.The aim of this study was to compare bone mass and structure between adolescents with type 1 diabetes and their healthy peers.Peripheral quantitative computed tomography (pQCT) at radius and tibia, and dual-energy X-ray absorptiometry (DXA) at lumbar spine and proximal femur were performed for 48 adolescents, 26 girls and 22 boys, with type 1 diabetes, and for healthy peers matched for age, sex, body height and weight, and pubertal maturity.Diabetes was associated with reduced bone mineral content (BMC) and smaller bone cross-sectional size. Diabetic boys seemed to be more affected than diabetic girls. Among the boys, the mean deficit in BMC of all measured skeletal sites was more than 10%, while among the girls it was less than 5%.In conclusion, type 1 diabetes is associated with reduced BMC and appears to affect bone cross-sectional size and cortical rigidity. The diabetes-related skeletal deficits seemed to concern male adolescents more than females. Whether diabetes-related deficits would contribute to an increased risk of fractures in adulthood or later in life remains to be confirmed. |
| Databáze: | OpenAIRE |
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