Ameliorative Effect of Dangguibuxue Decoction against Cyclophosphamide-Induced Heart Injury in Mice
| Autor: | Xiu-mei Ren, Qing-Sheng You, Wei-Nan Li, Qing Ye, Ming-Ming Gu, Shuo Wang, Kun Liu, Fei Wang, Chun-Hui Ma |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Blood Platelets
0301 basic medicine Heart Injury Article Subject Cyclophosphamide lcsh:Medicine Pharmacology General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences White blood cell Leukocytes medicine Animals Humans Platelet Aspartate Aminotransferases Creatine Kinase Pathological L-Lactate Dehydrogenase General Immunology and Microbiology biology business.industry lcsh:R NF-kappa B Alanine Transaminase Heart General Medicine 030104 developmental biology medicine.anatomical_structure Heart Injuries biology.protein Creatine kinase Dangguibuxue decoction Signal transduction business Drugs Chinese Herbal Signal Transduction medicine.drug Research Article |
| Zdroj: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| ISSN: | 2314-6141 2314-6133 |
| Popis: | Dangguibuxue decoction (DBD), a kind of Chinese herbal medicine, has been widely used to treat blood deficiency disease in China. In this experiment, we studied the effects of the Dangguibuxue decoction (DBD) on the myocardial injury induced by cyclophosphamide in mice. Alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatine kinase (CK), and lactic dehydrogenase (LDH) in serum were detected by commercial kits. Total white blood cell (WBCs), platelets, and cytokines pathological changes of heart tissue were also examined. In addition, the protein levels of the NF-кB pathway were detected to reveal its mechanism. The results showed that DBD significantly decreased the levels of ALT, AST, CK, and LDH and increased WBCs in CTX-induced mice. In addition, DBD significantly alleviated pathological changes of heart tissue. DBD significantly reduced the protein expressions of NF-кB signaling pathway. In summary, DBD can be considered an effective drug to alleviate CTX-induced heart damage in mice. |
| Databáze: | OpenAIRE |
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