Salivary biomarkers associated with perceived satiety and body mass in humans
| Autor: | Harthoorn, L.F., Schipper, R.G., Loof, A., van Heerde, W., Cordewener, J.H.G., America, A.H.P., Vereijken, P.F.G., Dransfield, E. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
medicine.medical_specialty
Saliva insulin Clinical Biochemistry Overweight Peptide hormone Energy homeostasis spectrometry Internal medicine medicine histatins VLAG ionization-time Chemistry food-intake proteomic analysis PRI Bioscience PRI Biometris Endocrinology ghrelin Proteome Biomarker (medicine) identification Ghrelin medicine.symptom Body mass index 2-dimensional gel-electrophoresis human whole saliva |
| Zdroj: | Proteomics Clinical Applications, 1(12), 1637-1650 Proteomics Clinical Applications 1 (2007) 12 |
| ISSN: | 1862-8346 |
| DOI: | 10.1002/prca.200700448 |
| Popis: | Regulation of food intake and energy homeostasis is controlled by a delicate balancing of numerous central and peripheral factors, including circulating peptide hormones. This study investigated the proteome of saliva using SELDI-TOF-MS in relation to satiety and body mass index (BMI) in humans. Within a longitudinal test session, 18 subjects were exposed to a lunch-induced hunger-satiety shift, while every 15 min collecting their whole saliva and rating their hunger and satiety. Saliva was analysed by SELDI-TOF-MS using IMAC arrays with a chromatographic copper surface (IMAC-Cu). From all subjects and time points measured, peptide and protein profiles showed 190 common peaks. Their interrelationships show that 37% of the variation was accounted for in one dimension. About 30 means had a strong association (0.70 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text