Effects of different extracts of Eugenia caryophyllata on pentylenetetrazole-induced seizures in mice
| Autor: | Navid Seddighi, Mahmoud Hosseini, Hamid Reza Sadeghnia, Mohammad Parvaneh, Hassan Rakhshandeh, Taha Jafarianheris, Ahmad Ghorbani |
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| Rok vydání: | 2012 |
| Předmět: |
Male
Aqueous extract Mice Inbred BALB C Future studies Dose-Response Relationship Drug Plant Extracts Chemistry Syzygium medicine.medical_treatment Clonic seizure Pharmacology Mice Dose–response relationship Anticonvulsant Complementary and alternative medicine Seizures Convulsion medicine Animals Pentylenetetrazole Anticonvulsants medicine.symptom Eugenia caryophyllata Saline |
| Zdroj: | Journal of Chinese Integrative Medicine. 10:1476-1481 |
| ISSN: | 1672-1977 |
| DOI: | 10.3736/jcim20121222 |
| Popis: | OBJECTIVE To investigate the possible anticonvulsant effect of different extracts of Eugenia caryophyllata (clove) on pentylenetetrazole (PTZ)-induced seizures in mice. METHODS The animals were divided into saline, 50, 100, 250 and 500 mg/kg of aqueous extract, 50, 100, 250 and 500 mg/kg of ethanolic extract, and 50, 100, 250 and 500 mg/kg of chloroformic extract of clove groups. The extracts or saline were injected 60 min before each PTZ injection. Latency to the first minimal clonic seizure (MCS) and generalized tonic-clonic seizure (GTCS) and the percent of mortality were recorded. RESULTS Aqueous extract of clove at doses of 50, 100, 250 and 500 mg/kg significantly extended the MCS and GTCS latency (P |
| Databáze: | OpenAIRE |
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