Inflammation appears as high Prostate Imaging–Reporting and Data System scores on prostate magnetic resonance imaging (MRI) leading to false positive MRI fusion biopsy
| Autor: | Dharam Kaushik, Daniel D Mais, Vishal Kukkar, Elizabeth Rourke, John DiGiovanni, Abhijit G Sunnapwar, Michael A. Liss |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Image-Guided Biopsy
Male medicine.medical_specialty Prostate biopsy Urology 030232 urology & nephrology Prostatitis Magnetic Resonance Imaging Interventional lcsh:RC870-923 Lesion 03 medical and health sciences Prostate cancer 0302 clinical medicine Magnetic resonance imaging Infection/Inflammation Prostate Biopsy medicine Data Systems Humans False Positive Reactions Ultrasonography Interventional Aged Retrospective Studies Inflammation medicine.diagnostic_test business.industry Cancer Middle Aged medicine.disease lcsh:Diseases of the genitourinary system. Urology 3. Good health medicine.anatomical_structure 030220 oncology & carcinogenesis Original Article Radiology Prostatic neoplasms medicine.symptom business |
| Zdroj: | Investigative and Clinical Urology, Vol 60, Iss 5, Pp 388-395 (2019) Investigative and Clinical Urology |
| ISSN: | 2466-0493 |
| Popis: | Purpose To investigate if inflammation as a potential cause of false-positive lesions from recent UroNav magnetic resonance imaging (MRI) fusion prostate biopsy patients. Materials and methods We retrospectively identified 43 men with 61 MRI lesions noted on prostate MRI before MRI ultrasound-guided fusion prostate biopsy. Men underwent MRI with 3T Siemens TIM Trio MRI system (Siemens AG, Germany), and lesions were identified and marked in DynaCAD system (Invivo Corporation, USA) with subsequent biopsy with MRI fusion with UroNav. We obtained targeted and standard 12-core needle biopsies. We retrospectively reviewed pathology reports for inflammation. Results We noted a total of 43 (70.5%) false-positive lesions with 28 having no cancer on any cores, and 15 lesions with cancer noted on systematic biopsy but not in the target region. Of the men with cancer, 6 of the false positive lesions had inflammation in the location of the targeted region of interest (40.0%, 6/15). However, when we examine the 21/28 lesions with an identified lesion on MRI with no cancer in all cores, 54.5% had inflammation on prostate biopsy pathology (12/22, p=0.024). We noted the highest proportion of inflammation. Conclusions Inflammation can confound the interpretation of MRI by mimicking prostate cancer. We suggested focused efforts to differentiate inflammation and cancer on prostate MRI. |
| Databáze: | OpenAIRE |
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