Randomized Trial of Mindfulness-Based Stress Reduction in Cardiac Patients Eligible for Cardiac Rehabilitation
| Autor: | Mary Jo Kreitzer, Priya Balaji, Alexandra G. Wolfe, Nitya V. Chandiramani, Susan A. Everson-Rose, Aaron Pergolski, Xiaohui Yu, Marsha Burt, Ruth Lindquist, Prabhjot S. Nijjar, John E. Connett, Roland Brown |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Mindfulness medicine.medical_treatment Myocardial Infarction lcsh:Medicine Blood Pressure Pilot Projects 030204 cardiovascular system & hematology Anxiety law.invention 0302 clinical medicine Randomized controlled trial law Secondary Prevention 030212 general & internal medicine lcsh:Science Depression (differential diagnoses) education.field_of_study Multidisciplinary Rehabilitation Cardiac Rehabilitation Depression Middle Aged Lipids 3. Good health C-Reactive Protein Meditation Female medicine.symptom Psychosocial medicine.medical_specialty Population Cardiology Article Mindfulness-based stress reduction 03 medical and health sciences medicine Humans education Aged Glycated Hemoglobin business.industry lcsh:R Health care Physical therapy Quality of Life lcsh:Q business Biomarkers Stress Psychological |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Currently, exercise-based cardiac rehabilitation (CR) is the only recommended secondary prevention strategy for cardiac patients that attempts to tackle stress and psychosocial wellbeing, but it is under-utilized and lacks a comprehensive curriculum for this purpose; hence there is a critical gap to address psychosocial needs of cardiac patients after an event. Mindfulness-based stress reduction (MBSR) has shown benefits in the general population but its role in cardiac patients is not clear. We conducted a pilot randomized controlled trial (RCT) of MBSR in CR-eligible cardiac patients during their initial year of recovery. Patients were allocated 2:1 (intervention:control) to an 8-week MBSR group intervention or usual care. Standard measures of depression, anxiety, perceived stress, health related quality of life (HRQOL), blood pressure, biomarkers (lipids, HbA1c, CRP) and 24-hour Holter monitoring were obtained at baseline, 3- and 9-months post-randomization. Sub-group analyses were performed for participants with at least mild depression (PHQ-9 ≥ 5). 47 patients [mean age 58.6 years; 38% female; 77% white] were enrolled in 2 cohorts. 87% of MBSR patients completed the intervention; study retention was >95% at each follow-up visit. At 3 months, compared to controls, MBSR patients showed improvements in depression [p = 0.01] and anxiety [p = 0.04] with a similar trend in HRQOL [p = 0.06]. The MBSR group showed greater improvement or less worsening of most CV risk factors, with an attenuation of treatment effects at 9 months. Participants with at PHQ-9 scores ≥5 at baseline showed greater improvement in psychosocial and CV outcomes, that persisted at 9 months. MBSR is a safe and well received secondary prevention strategy. This pilot RCT provides preliminary evidence of MBSR’s potential to improve short term psychosocial well-being in cardiac patients during their first year of recovery. |
| Databáze: | OpenAIRE |
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