Longitudinal Telomere Erosion in Lymphocyte Subsets of Patients with Atherosclerotic Peripheral Arterial Disease (PAD)
| Autor: | Jan Völzmann, Dirk de Beer, Christoph Kalka, Gabriela M. Baerlocher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Internal Medicine Section
arteriosclerosis business.industry Arterial disease Vascular disease Clinical Biochemistry lcsh:R lcsh:Medicine General Medicine Arteriosclerosis Disease medicine.disease Peripheral Telomere pad Immunology telomere length Medicine cad business 610 Medicine & health Normal range Lymphocyte subsets |
| Zdroj: | Journal of Clinical and Diagnostic Research, Vol 9, Iss 3, Pp OM01-OM03 (2015) |
| DOI: | 10.7892/boris.80283 |
| Popis: | Telomere attrition has been linked to accelerate vascular ageing and seems to predispose for vascular disease. Our aim was to study the telomere length dynamics over time and in subsets of leukocytes from 15 patients with peripheral arterial disease (PAD). The mean telomere length in subsets of leukocytes of patients with PAD was in the normal range of age-related telomere length values from healthy individuals. However, we found significant higher telomere attrition for T-cells from patients with PAD over a time period of six months when compared to the controls. The higher telomere loss in T-cells of patients with PAD most likely reflects a higher cell turnover of this leukocyte subset, which is involved in the process of chronic inflammatory disease underlying vascular disease. Further studies are needed to confirm these data and to assess how far this T-cell telomere attrition will correlate to the extent of the disease. |
| Databáze: | OpenAIRE |
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