Eft ofSchizonepeta TenuifoliaExtract On Mast Cell-Mediated Immediate-Type Hypersensitivity In Rats
| Autor: | Hyun-A Kim, Jun Sm, Hyun-Ja Jeong, Hyung-Ryong Kim, Tae-Yong Shin, Baek Sh, Han-Jung Chae |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_treatment
Immunology Dose-Response Relationship Immunologic Pharmacology Toxicology Immunoglobulin E Histamine Release chemistry.chemical_compound medicine Animals p-Methoxy-N-methylphenethylamine Immunology and Allergy Mast Cells Rats Wistar Anaphylaxis Peritoneal Cavity Lamiaceae Plants Medicinal biology Plant Extracts Tumor Necrosis Factor-alpha Chemistry Passive Cutaneous Anaphylaxis Biological activity General Medicine Mast cell Rats Dose–response relationship medicine.anatomical_structure Cytokine Mechanism of action biology.protein Tumor necrosis factor alpha medicine.symptom Dinitrophenols Histamine |
| Zdroj: | Immunopharmacology and Immunotoxicology. 21:705-715 |
| ISSN: | 1532-2513 0892-3973 |
| DOI: | 10.3109/08923979909007136 |
| Popis: | We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose-dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-alpha (TNF-alpha) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-alpha production from RPMC. |
| Databáze: | OpenAIRE |
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